专利号:WO-2004011474-A1 优先权日:2002-07-31 标题:Universal support media for synthesis of oligomeric compounds 发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K 权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K 摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.
专利号:US-6653468-B1 优先权日:2002-07-31 标 题 :Universal support media for synthesis of oligomeric compounds 发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH 权利人:ISIS PHARMACEUTICALS INC 摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.
专利号:US-4810649-A 优先权日:1984-04-06 标题:Controlled regeneration of zea diploperennis hybrids and breeding strategies therewith 发明人:SONDAHL MARO R; EVANS DAVID A; PRIOLI LAUDENIR 权利人:DNA PLANT TECHN CORP 摘要:This invention provides a method for high frequency plant regeneration from somatic stem donor tissue of field grown Zea diploperennis, a diploid, perennial corn ancestor with high tillering capacity. This species is used as a parent in a maize improvement strategy to transfer the unique traits of high tillering and plantlet regeneration capacity into cultivated corn. After 3-4 subcultures of cultured somatic tissues on a primary medium, small callus fragments are transferred to a secondary medium devoid of the auxin, 2,4-D. After a few days, numerous shoots regenerate and develop into normal plantlets which are then separated and transferred to a tertiary medium for root development. The selection of somaclonal variants form cultured somatic cells of interspecific hybrids between corn and teosinte are used for the synthesis of unique breeding lines suited for development of improved corn varieties. A protocol for gene transfer employing recombinant DNA techniques is also described.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-2016073631-A1 优先权日:2013-03-04 标 题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:US-5231085-A 优先权日:1988-10-31 标题 :Compositions and methods for the enhancement of host defense mechanisms 发明人:ALEXANDER J WESLEY; BABAYAN VIGEN K; BLACKBURN GEORGE L; CERRA FRANK B; DALY JOHN; GERSOVITZ MITCHELL T; KINSELLA JOHN E; LICARI JEROME J; RUDOLPH FREDERICK; VAN BUREN CHARLES T 权利人:SANDOZ LTD 摘要:The invention provides immunostimulatory compositions comprising an aggregate immunostimulatory amount of n a) a compound associated with the synthesis of polyamines, n b) a nucleobase source, n c) omega-3 polyunsaturated fatty acids, and n d) omega-6 polyunsaturated fatty acids n the use of such compositions and their manufacture.
1: Nesakumar N, Sethuraman S, Krishnan UM, Rayappan JB. Cyclic voltammetric acetylcholinesterase biosensor for the detection of captan in apple samples with the aid of chemometrics. Anal Bioanal Chem. 2015 Jun;407(16):4863-8. doi: 10.1007/s00216-015-8687-1. Epub 2015 Apr 21. doi: 10.1016/j.toxlet.2011.09.023. Epub 2011 Sep 29. doi: 10.1007/s00128-015-1705-3. Epub 2015 Nov 26. doi: 10.1111/1556-4029.12154. Epub 2013 May 21. doi: 10.1038/jes.2015.54. Epub 2015 Sep 16. 6: Berthet A, Bouchard M, Danuser B. Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers. J Appl Toxicol. 2012 Mar;32(3):194-201. doi: 10.1002/jat.1653. Epub 2011 Mar 5. doi: 10.1080/19440049.2013.790088. Epub 2013 May 28. doi: 10.1093/annhyg/mer008. Epub 2011 Mar 22. 9: Boran H, Capkin E, Altinok I, Terzi E. Assessment of acute toxicity and histopathology of the fungicide captan in rainbow trout. Exp Toxicol Pathol. 2012 Mar;64(3):175-9. doi: 10.1016/j.etp.2010.08.003. Epub 2010 Sep 2. doi: 10.1080/03601234.2015.1062648. Epub 2015 Aug 7. doi: 10.1080/19440049.2013.794977. Epub 2013 Jun 7. doi: 10.1093/annhyg/mes011. Epub 2012 Mar 16. doi: 10.1021/jf1030339. Epub 2010 Dec 1. doi: 10.1002/jat.1659. Epub 2011 Mar 5. doi: 10.3109/10408444.2010.481663. Review. doi: 10.1021/es9037935. doi: 10.1007/s00216-010-4601-z. Epub 2011 Jan 13. ^
合成参考文献
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