CAS: 134978-97-5; 2-(2-(2-Aminoethoxy)Ethoxy)Acetic Acid

相似化合物

134979-01-4 166108-71-0 108466-89-3

上下游产品

CAS号882518-90-3 Azido-PEG2-CH2COOH | CAS号166108-71-0 [2-[2-(Fm°C-氨基)... | CAS号166108-71-0 [2-[2-(Fm°C-氨基)...

2-[2-(Phthalimidoethoxy)-Ethoxy]-Acetic Acid Ethyl Ester置于sodium Hydroxide体系中,用 乙醇 用作溶剂,化学反应生成2-(2-(2-氨基乙氧基)乙氧基)乙酸
参考文献:一种[2-[1-(Fmoc-氨基)乙氧基]乙氧基]乙酸的制备方法
标题:一种[2-[1-(Fmoc-氨基)乙氧基]乙氧基]乙酸的制备方法
摘要:本发明提供了一种[2‑[1‑(Fmoc‑氨基)乙氧基]乙氧基]乙酸的制备方法,包括:以邻苯二甲酸酐对二甘醇胺进行氨基保护,所得中间体与卤代乙酸或卤代乙酸酯反应后,进行脱保护或者脱保护和水解,与fomc基氨基保护试剂反应后纯化,得到[2‑[1‑(Fmoc‑氨基)乙氧基]乙氧基]乙酸.本发明中,以邻苯二甲酸酐和二甘醇胺为起始原料,氨基保护反应所需时间短,且所得中间体化合物稳定性好,可长期保存,且与水不发生反应,可以通过萃取将水溶性杂质(原料二甘醇胺和副产物邻苯二甲酸等)分离,从而得到具有高纯度的氨基保护产物,而这也有利于目标产物纯度和得率的提高.

专利信息

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:US-11186608-B2
优先权日:2017-12-21
标 题 :Solid phase synthesis of acylated peptides
发明人：SCHOENLEBER RALPH O; LOIDL GUENTHER
权利人:BACHEM HOLDING AG
摘要:The present invention relates to methods and compounds for the solid phase synthesis of peptides carrying a substituent at an amino group of an amino acid side chain.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.