CAS: 1516-08-1; Ethanol-D6

上下游产品

CAS号64-17-5 乙醇 | CAS号3675-63-6 氘代溴乙烷 | CAS号558-37-2 3,3-二甲基-1-丁烯 | CAS号6485-58-1 碘乙烷-d5 | CAS号2679-89-2 乙醚-d10 | CAS号683-73-8 乙烯-d4 | CAS号117121-81-0 乙酸乙酯-d8 | CAS号57413-43-1 混旋哌乙酯碱

氘代甲醇置于silicon Dopped N-Type Gan Nano Wire体系中,化学反应 12.0H,反应生成氘代乙醇
参考文献:通过甲基碳直接催化甲醇制乙醇的光转化
标题:通过甲基碳直接催化甲醇制乙醇的光转化
摘要:作为确保可持续的"化石替代品"的重要努力,将更容易获得的甲醇直接转化为更人性化,毒性更小和适用范围更广的乙醇构成了令人兴奋的潜力以及巨大的科学挑战.本文中,我们报道了在环境温度下,由超稳定氮化镓半导体催化的甲醇向乙醇的光驱动单步转化.机理研究表明,甲基卡宾(亚甲基)是合成化学中最引人入胜的c 1结构单元之一,是作为反应中间体生成的,这有可能成为一种绿色且新颖的卡宾生成方法.我们还发现甲醇可以转化为正-丙醇与相同的催化剂通过简单地改变反应温度,得到独特的选择性和高附加值的产物.
Doi:10.1016/j.Chempr.2019.01.005

专利信息

专利号:US-8829238-B2
优先权日:2011-09-22
标 题:Methods for the synthesis of deuterated acrylate salts
发明人：YANG JUN; BONNESEN PETER V; HONG KUNLUN
权利人:YANG JUN; BONNESEN PETER V; HONG KUNLUN; UT BATTELLE LLC
摘要:A method for synthesizing a deuterated acrylate of the Formula (1), the method comprising: (i) deuterating a propiolate compound of Formula (2) to a methyne-deuterated propiolate compound of Formula (3) in the presence of a base and D 2 O: and (ii) reductively deuterating the methyne-deuterated propiolate compound of Formula (3) in a reaction solvent in the presence of deuterium gas and a palladium-containing catalyst to afford the deuterated acrylate of the Formula (1). The resulting deuterated acrylate compounds, derivatives thereof, and polymers derived therefrom are also described.

专利号:US-2024059678-A1
优先权日:2021-01-18
标 题 :Synthesis Method for Aminopyrimidine FAK Inhibitor Compound
发明人：DU WU; LV HAIBIN; LI YU; KUANG TONGTAO; GENG XI
权利人:HINOVA PHARMACEUTICALS INC
摘要:A synthesis method for an aminopyrimidine FAK inhibitor compound, relating to the field of pharmaceutical synthesis. In the synthesis method, R1 is hydrogen or a carboxylic acid protecting group, R2 is selected from C1ËœC6 alkyl or C1ËœC6 deuterated alkyl, R3 and R4 are each independently selected from hydrogen or deuterium, and R5 is selected from C1ËœC6 alkyl or C1ËœC6 deuterated alkyl. The synthesis method is simple to operate, and has low costs. The product prepared can obtain a high total yield (≥66%) and a high purity (≥99%), and the product yield and purity are superior to those in the prior art (in the prior art, the total yield is about 11%, and the purity is 99%). The synthesis method achieves excellent effects, can also successfully prepare a final product on kilogram scale, and is suitable for industrial production, having a good application prospect.

专利号:US-2024286990-A1
优先权日:2021-06-18
标题:Vinylated keto esters with applicability in signal enhanced magnetic resonance imaging and synthesis thereof
发明人：GLÖGGLER STEFAN; KORCHAK SERGEY; JAGTAP ANIL P; SAUL PHILIP; MOLL DENIS
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a vinyl keto ester and intermediates of its synthesis, wherein the vinyl moiety of the vinyl hydroxy ester and of the intermediates is partly or fully deuterated. Furthermore, the present invention relates to two alternative methods of preparing said vinyl keto ester. The first method is a multi-step approach comprising the steps of providing a carboxylic acid that comprises a geminal diol moiety protected by a photolabile protecting group, vinylating said carboxylic acid using vinyl acetate, and cleaving the protecting group by applying UV light. The second method is a one-step approach of reacting a carboxylic acid that comprises an additional carbonyl moiety with acetylene in the presence of a metal catalyst. In both methods, the compounds used may be fully or partly deuterated.

专利号:US-8952042-B2
优先权日:2009-08-19
标 题 :FXR (NR1H4) binding and activity modulating compounds
发明人：KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF
权利人:KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF; PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds of formula (1): n nwhere R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt thereof. These compounds bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

专利号:US-2013079554-A1
优先权日:2011-09-22
标 题 :Methods for the synthesis of deuterated acrylate salts

专利号:US-8633204-B2
优先权日:2006-09-15
标 题 :4-methylpyridopyrimidinone compounds
发明人：CHENG HENGMIAO; BHUMRALKAR DILIP; DRESS KLAUS RUPRECHT; HOFFMAN JACQUI ELIZABETH; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; LE PHUONG THI QUY; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; PLEWE MICHAEL BRUNO; TRAN KHANH TUAN
权利人:CHENG HENGMIAO; BHUMRALKAR DILIP; DRESS KLAUS RUPRECHT; HOFFMAN JACQUI ELIZABETH; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; LE PHUONG THI QUY; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; PLEWE MICHAEL BRUNO; TRAN KHANH TUAN; PFIZER
摘要:The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), n nand to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kα).