CAS: 25501-32-0; (S)-2,3-Dihydro-1H-Inden-1-Ol

上下游产品

CAS号6351-10-6 1-茚醇 | CAS号83-33-0 1-茚酮 | CAS号68567-23-7 acetic acid,(1S... | CAS号638-11-9 丁酸异丙基酯 | CAS号95-13-6 茚 | CAS号496-11-7 茚满 | CAS号144-79-6 二苯基甲基氯硅烷 | CAS号994-30-9 三乙基氯硅烷 | CAS号768-33-2 二甲基苯基氯硅烷 | CAS号108-22-5 醋酸异丙烯酯 | CAS号83-33-0 1-茚酮 | CAS号697-64-3 R-(-)-1-茚酚 | CAS号6351-10-6 1-茚醇

1-茚酮置于c32H41Crn3O2Si,C7H14O4Si,Potassium Carbonate体系中,用 甲苯,甲醇 用作溶剂,化学反应 3.0H,以89%的收率获得(S)-(+)-1-茚醇
参考文献:开放的d壳增强了3D金属催化的活性空间:高度对映选择性的铬(II)夹钳催化的酮的氢化硅烷化†
标题:开放的d壳增强了3D金属催化的活性空间:高度对映选择性的铬(II)夹钳催化的酮的氢化硅烷化†
摘要:双(恶唑啉基二甲基甲基)吡咯(pdmbox)立体定向配体为铬(II)催化的酮的高对映选择性氢化硅烷化提供了关键.发现一种稀有的方形平面手性铬(II)烷基络合物可作为有效的预催化剂,用于还原各种芳基烷基和二烷基酮衍生物.铬的开放d 4壳的立体电子偏好(II)将分子催化剂牢牢地锁定在正方形平面几何形状中,从而产生了配位球的两个封闭象限.在温和的反应条件(−40oc至室温)和低催化剂负载量(低至0.5 Mol%)下,这种富含地球的贱金属催化平台可产生优异的分离收率,高达98%ee的相应手性醇.
Doi:10.1039/c8Cc05172K

专利信息

专利号:US-9388147-B2
优先权日:2009-11-13
标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN
权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ RL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-9394264-B2
优先权日:2009-11-13
标 题:Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA
权利人:RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-7476757-B2
优先权日:2005-02-22
标 题:Process for the synthesis of enantiomeric indanylamine derivatives
发明人：BOULTON LEE TERENCE; LENNON IAN CAMPBELL; BAHAR ELIEZER
权利人:TEVA PHARMA
摘要:A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or pressure hydrogenation in the presenc of an optically active catalyst to reduce 1-indanones. The chiral product, either (S)- or (R)-indanols undergo nucleophilic substitution to produce the named product. In an additional aspect, the invention relates to novel intermediates and compounds, namely, substituted indanones, substituted (S)-indanols and substituted (R)-indanols.

专利号:US-2006199974-A1
优先权日:2005-02-22
标 题:Process for the synthesis of enantiomeric indanylamine derivatives

专利号:US-2008200720-A1
优先权日:2005-02-22
标题:Process for the synthesis of enantiomeric indanylamine derivatives

专利号:US-7375249-B2
优先权日:2005-02-22
标 题:Process for the synthesis of enantiomeric indanylamine derivatives