CAS: 27538-09-6; 5-Ethyl-4-Hydroxy-2-Methylfuran-3(2H)-One

相似化合物

3658-77-3 27538-10-9 4166-20-5

3-Heptyn-2,5-Diyl Bis(Tert-Butyl Carbonate)置于potassium Permanganate,草酸,溶剂黄146体系中,用 丙酮 用作溶剂,化学反应 10.5H,反应生成5-乙基-4-羟基-2-甲基-3(2H)-呋喃酮
参考文献:Determination Of 4-Hydroxy-2,5-Dimethyl-3(2H)-Furanone And 2(Or 5)-Ethyl-4-Hydroxy-5(Or 2)-Methyl-3(2H)-Furanone In Pentose Sugar-Based Maillard Model Systems By Isotope Dilution Assays
标题:Determination Of 4-Hydroxy-2,5-Dimethyl-3(2H)-Furanone And 2(Or 5)-Ethyl-4-Hydroxy-5(Or 2)-Methyl-3(2H)-Furanone In Pentose Sugar-Based Maillard Model Systems By Isotope Dilution Assays
摘要:The Formation Of 4-Hydroxy-2,5-Dimethyl-3(2H)-Furanone (Hdmf) And 2(Or 5)-Ethyl-4-Hydroxy-5(Or 2)-Methyl-3(2H)-Furanone (Ehmf) From Pentose Sugars Was Studied In Maillard Model Systems. The Amounts Generated At 90 Degrees C For 1 H Were Determined By Isotope Dilution Assay (Ida). The Internal Standards Used For Ida,I.E.,[c-13(2)]Hdmf And [h-2(3)]Ehmf,Were Prepared In Good Overall Yields In Three Steps: Addition Of Labeled Acetaldehyde Or Propionaldehyde To Tert-Butyloxycarbonyl (Boc)-Protected And Lithiated 3-Butyn-2-Ol; Oxidation Of The Boc-Protected Diol With Permanganate To 1,2-Dione; And Finally Cyclization To The Target Molecules After Removal Of The Protective Groups Under Acidic Conditions. Quantitative Data Confirmed Previous Findings That Hdmf And Ehmf Are Preferentially Formed In The Presence Of Glycine And L-Alanine,Respectively. The Yields Obtained Were 2.6-5.1 Mu G Of Hdmf And 6.8-10 Mu G Of Ehmf Per Mmol Pentose. Formation Of Both Furanones Was Favored In Phosphate-Buffered Solutions At Ph 7 Compared To Ph 5,Particularly In The Presence Of An Excess Of Amino Acid. These Data Are Well In Agreement With The Previously Proposed Formation Mechanism Of Hdmf And Ehmf Via Strecker-Assisted Chain Elongation Of The Pentose Moiety. However,Both Furanones Were Also Produced To A Lesser Extent By Sugar Fragmentation-Condensation Reactions.
Doi:10.1021/jf960997I

专利信息

专利号:US-2014228554-A1
优先权日:2011-03-18
标 题:Synthesis of new fucose-containing carbohydrate derivatives
发明人：CHAMPION ELISE; DEKANY GYULA; HEDEROS MARKUS; AGOSTON KAROLY
权利人:GLYCOM AS; GLYCOM AS
摘要:A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R 1 or a salt thereof, wherein A and R 1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided. The fucooligosaccharid glycoside compounds, or derivatives thereof, their use in the manufacture of human milk oligosaccharides, and a method of manufacture of human milk oligosaccharides, are also provided.

专利号:EP-2686330-A1
优先权日:2011-03-18
标题 :Synthesis of new fucose-containing carbohydrate derivatives

专利号:WO-2012127410-A1
优先权日:2011-03-18
标 题 :Synthesis of new fucose-containing carbohydrate derivatives