CAS: 31719-77-4; 3-(Chloromethyl)Benzoic Acid

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CAS号99-04-7 间甲基苯甲酸 | CAS号93-58-3 苯甲酸甲酯 | CAS号50-00-0 甲醛 | CAS号64407-07-4 间氰基氯苄 | CAS号542-88-1 二氯甲基醚 | CAS号65-85-0 苯甲酸 | CAS号34040-63-6 3-氯甲基苯甲酸甲酯 | CAS号41908-12-7 3'-氯甲基苯乙酮 | CAS号3010-83-1 3,3-二羧基二苯基甲烷 | CAS号876-03-9 3-氨甲基苯甲酸盐酸盐 | CAS号63024-77-1 3-(氯甲基)苯甲酰氯 | CAS号54589-54-7 3-氯甲基苯甲酸乙酯 | CAS号99-04-7 间甲基苯甲酸 | CAS号126062-63-3 3-溴甲基苯甲酸叔丁酯 | CAS号646511-09-3 3-(nitrooxymeth...

间甲基苯腈置于水,氯,Sodium Hydroxide体系中,用 四氯化碳 用作溶剂,化学反应 4.0H,反应生成3-(氯甲基)苯甲酸
参考文献:一种3-羧基苯甲醛的制备方法
标题:一种3-羧基苯甲醛的制备方法
摘要:本发明公开一种3‑羧基苯甲醛的制备方法,包括以下步骤:以间甲基苯腈为起始原料,进行第一水解反应,然后加酸进行酸化反应,得到间甲基苯甲酸;将间甲基苯甲酸进行氯代反应,得到3‑羧基苄基氯;将3‑羧基苄基氯和乌洛托品混合,进行氧化反应,然后加冰醋酸和水进行第二水解反应,得到3‑羧基苯甲醛.本发明方法以成本低廉的间甲基苯腈为原料,经水解,氯代,氧化和水解一系列过程合成3‑羧基苯甲醛,产物纯度和收率均较高;本发明方法工艺操作简单,安全,所用原料易于得到,且成本低,适合于工业生产.

专利信息

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-5712367-A
优先权日:1989-10-02
标 题:Process for the solubilization of peptides and process for peptide synthesis
发明人：BERNARD JEAN-MARIE; BOUZID KAMEL; GERVAIS CHRISTIAN
权利人:RHONE POULENC CHIMIE
摘要:A process is disclosed for making peptides soluble in a water-immiscible organic solvent, comprising linking a lipophilic group with an amide or ester bond to the terminal carboxyl group of said peptide; when the lipophilic group is linked to L-serine, a molecule is obtained with a solubility in water at 25 DEG C. of less than 30 g/liter. This lipophilic group is non-polymeric and chemically defined. A process is also disclosed for the synthesis of peptides, optionally protected, in a liquid medium, wherein the starting material is an amino acid or peptide made soluble in an organic medium by a lipophilic group A-L linked to the carboxyl function of the starting amino acid or peptide, and are added to amino acids or peptides to be condensed which are activated on their acid function and protected on their amine function and are optionally protected on their side chain. The peptides resulting from the synthesis are used, where appropriate, for the synthesis of medicinal products, vaccines or agri-foodstuff or plant-protection.

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

专利号:US-8580822-B2
优先权日:2006-12-11
标 题:Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
发明人：BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD
权利人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD; REVIVA PHARMACEUTICALS INC
摘要:The present invention provides novel indanone derivatives which can be advantageously used for treating and/or preventing of a medical condition for which inhibition of a cholinesterase is desired.

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

专利号:EP-1200824-B1
优先权日:1999-06-15
标题:Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives