CAS: 38696-21-8; 5-Bromo-N,N-Dimethylpyrimidin-2-Amine

相似化合物

31402-54-7 433684-23-2 77476-95-0

上下游产品

CAS号7752-82-1 2-氨基-5-溴嘧啶 | CAS号74-88-4 碘甲烷 | CAS号53939-30-3 5-溴-2-氯吡啶 | CAS号124-40-3 二甲胺 | CAS号5621-02-3 2-二甲氨基嘧啶 | CAS号506-59-2 盐酸二甲胺 | CAS号32779-36-5 5-溴-2-氯嘧啶 | CAS号1072-97-5 2-氨基-5-溴吡啶 | CAS号1032759-30-0 2-二甲基胺嘧啶-5-硼酸-2... | CAS号55338-76-6 2-(二甲氨基)嘧啶-5-腈 | CAS号56621-99-9 N2,N2-二甲基-2,5-二氨基吡啶

2-二甲氨基嘧啶置于1,3-二溴-5,5-二甲基海因体系中,用 二氯甲烷 作为反应溶剂,以86%的收率获得产物5-溴-2-(二甲基氨基)嘧啶
参考文献:Syntheses And Properties Of Novel Liquid Crystals Containing A Trifluoromethylamino Group
标题:Syntheses And Properties Of Novel Liquid Crystals Containing A Trifluoromethylamino Group
摘要:含三氟甲基氨基团的液晶(lcs)是通过 P-溴取代的(杂)芳基(三氟甲基)胺与相应的二硫氨基甲酸酯经过氧化脱硫-氟化反应的交叉偶联反应制备的.新型液晶在较宽的温度范围内主要表现出层状相.它们作为向列相液晶的组成部分,其电光性能与相应的甲基胺进行了比较.
DOI:10.1246/bcsj.72.2523

专利信息

专利号:US-5304647-A
优先权日:1988-02-09
标题:Method of preparation of halogenated diazines
发明人：STREKOWSKI LUCJAN; MOKROSZ MARIA; HARDEN DONALD B
权利人:UNIV GEORGIA STATE
摘要:A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof. The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product. The substituted halogenodiazines are used as intermediates in the synthesis of unfused heterobicyclic compounds containing an aromatic moiety, diazine, and another aromatic moiety, such as thiophene, benzene, or naphthalene, which have biological activity.

专利号:US-4963676-A
优先权日:1988-02-09
标题 :Di-substituted phthalazines
发明人：STREKOWSKI LUCJAN; MOKROSZ MARIA; HARDEN DONALD B
权利人:UNIV GEORGIA STATE
摘要:A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof. The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product. The substituted halogenodiazines are used as intermediates in the synthesis of novel unfused heterobicyclic compounds containing an aromatic moiety, diazine, and another aromatic moiety, such as thiophene, benzene, or naphthalene, which have biological activity.