CAS: 587-04-2; 3-Chlorobenzaldehyde

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CAS号2929-92-2 acetic acid,(3-... | CAS号201230-82-2 carbon monoxide | CAS号625-99-0 3-氯碘苯 | CAS号873-63-2 3-氯苄醇 | CAS号2039-85-2 3-氯苯乙烯 | CAS号618-46-2 间氯苯甲酰氯 | CAS号766-84-7 3-氯苯腈 | CAS号4152-90-3 间氯苄胺 | CAS号1515-91-9 1-chloro-3-(met... | CAS号1878-65-5 3-氯苯乙酸 | CAS号1049677-64-6 2-氯-6-甲酰基-苯甲酸乙酯 | CAS号1047630-73-8 2-氨基-2-(3-氯苯基)乙... | CAS号106145-93-1 2-(3-chlorophen... | CAS号34784-06-0 7-氯异喹啉 | CAS号34784-07-1 8-氯异喹啉 | CAS号41024-33-3 2-溴-3-氯苯甲酸甲酯 | CAS号321-31-3 3'-氯-2,2,2-三氟苯乙酮 | CAS号33537-99-4 6-氯-1,2,3,4-四氢异喹啉 | CAS号34841-39-9 安非他酮 | CAS号34841-35-5 间氯苯丙酮

3-氯苯甲酸乙酯置于吗啉,二异丁基氢化铝体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 3.34H,以99%的收率获得产物3-氯苯甲醛
参考文献:使用二异丁基(吗啉代)铝将酯轻度和直接转化为吗啉酰胺:应用于从酯有效一锅合成酮和醛
标题:使用二异丁基(吗啉代)铝将酯轻度和直接转化为吗啉酰胺:应用于从酯有效一锅合成酮和醛
摘要:吗啉酰胺中间体很容易通过各种酯与二异丁基(吗啉代)铝的氨解反应制得,它与有机锂和还原剂(dibalh或ldbma)反应,而无需分离氨解中间体,可以定量得到83-95%的酮和醛.
DOI:10.1016/j.Tet.2014.03.045

专利信息

专利号:WO-8800592-A1
优先权日:1986-07-18
标题:DIASTEROSELECTIVE STRECKER SYNTHESIS OF alpha-AMINOACIDS FROM GLYCOSYLAMINE DERIVATES
发明人：KUNZ HORST; SAGER WILFRIED; PFRENGE WALDEMAR; DECKER MATHIAS
权利人:CELAMERCK GMBH & CO KG
摘要:O-acyl-protected glycosylamines, in particular 2,3,4,6-tetra-O-pivaloyl-beta-D-galactopyranosylamine (1), their preparation and their use for the diastereoselective synthesis of alpha-aminoacids. With compounds such as (1), one can obtain by Strecker synthesis high yields and high diastereomer surplus. The direction of the asymmetric induction can be determined by the selection of the solvent. This type of synthesis is particularly effective when carried with Lewis acid catalysts. One obtains also high yields and high diastereoselectivity during Ugi four component synthesis facilitated by Lewis acids by using amines such as (1).

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-2022356139-A1
优先权日:2019-09-03
标 题:Synthesis of deuterated aldehydes
发明人：WANG WEI
权利人:ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIV OF ARIZONA
摘要:Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D 2 O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

专利号:WO-2015109451-A1
优先权日:2014-01-22
标 题 :Synthesis of compounds containing 8-oxa-3-azabicyclo (3.2.1)octane ring
发明人：LI PENG; DECAMPO FLORYAN; SHI FENG; CUI XINJIANG; YUAN HANGKONG
权利人:RHODIA OPERATIONS; LANZHOU INSTITUTION OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCE
摘要:The present invention mainly pertains to catalytic processes for the direct amination of 2, -bis(hydroxymethyl) tetrahydrofuran to obtain compounds containing the 8-oxa-3-azabicyclo (3.2.1) octane ring, in the presence of: a homogenous catalyst which is a complex comprising at least one element selected from the group consisting of Iridium or Ruthenium and at least one donor ligand, or a heterogeneous catalyst comprising at least one Group 8-11 transition metal element and one poor metal element in the p-block of the period table.

专利号:US-11745159-B2
优先权日:2017-10-20
标题:Heated nanowells for polynucleotide synthesis
发明人：MARSH EUGENE P; INDERMUHLE PIERRE F; PECK BILL JAMES
权利人:TWIST BIOSCIENCE CORP
摘要:Defined sequence RNA synthesis by 3′→5′ direction is now well established and currently in use for synthesis and development of vast variety of therapeutic grade RNA and Si RNA etc. A number of such synthetic RNA requires a modification or labeling of 3′-end of an oligonucleotide. The synthesis of 3′-end modified RNA requiring lipophilic, long chain ligands or chromophores, using 3′→5′ synthesis methodology is challenging, requires corresponding solid support and generally results in low coupling efficiency and lower purity of the final oligonucleotide in general because of large amount of truncated sequences containing desired hydrophobic modification. We have approached this problem by developing reverse RNA monomer phosphoramidites for RNA synthesis in 5′→3′-direction. They lead to very clean oligonucleotide synthesis allowing for introduction of various modifications at the 3′-end.

专利号:US-2018208775-A1
优先权日:2014-06-23
标 题:New aromatic macrocyclic metal complex dyes and the synthesis thereof with active nano metal powders
发明人：OLGUN UGURSOY; YILDIZ SALIH ZEKI
权利人:OLGUN UGURSOY; YILDIZ SALIH ZEKI
摘要:The present invention relates to a new type of inorganic coordination compound dyes having advanced technology optical, electronic and medical characteristics and relates to production of these dyes by means of new synthesis methods. The present invention relates to dyes which are metal (M: Li, Na, K, Mg, Ca, Sr, Ba, Ti, Zr, V, Cr, Mo, Mn, Re, Fe, Ru, Co, Rh, Ir, Ni, Pd, Pt, Cu, Ag, Au, Zn, Cd, B, Al, Ga, In, Si, Ge, Sn, Pb, Sb, Bi, Se, Te) complexes of aromatic macrocyclic compounds of the type Phtalocyanine (Pc), Naphtalocyanine (Nc), Porphyrazine (Pz), Porphyrin (Pr), sub-Phtalocyanine (subPc), sub-Naphtalocyanine (subNc), sub-Porphyrazine (subPz), sub-Porphyrine (subPr), and relates to the synthesis of these complexes and derivatives. The subject matter dyes can be used in solar cell photovoltaic (PV) panels, in OLEDS which are organic structured light emitting diodes, in polymers, in textile and in photodynamic therapy PDT applications. Moreover, industrial applications are possible which depend on strong fluorescence characteristics.