CAS: 864731-61-3; 4-(5-(3,5-Dichlorophenyl)-5-(Trifluoromethyl)-4,5-Dihydroisoxazol-3-yl)-2-Methyl-N-(2-Oxo-2-((2,2,2-Trifluoroethyl)Amino)Ethyl)Benzamide

上下游产品

trifluoroethylamine carbon monoxide 2-ammonia-N-(2,2,2-trifluoroethyl)acetamide 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

4-溴-2-甲基苯甲酸置于4-二甲氨基吡啶,Tris-(Dibenzylideneacetone)Dipalladium(0),二碳酸二叔丁酯,Caesium Carbonate,O-(1H-Benzotriazol-1-yl)-N,N,N',N'-Tetramethyluronium Hexafluorophosphate,三乙胺,2-二环己基磷-2,4,6-三异丙基联苯体系中,用 乙二醇二甲醚,N,N-二甲基甲酰胺,甲苯 作为反应溶剂,化学反应 24.67H,反应生成 氟雷拉纳
参考文献:一种异噁唑啉杀虫剂的制备方法
标题:一种异噁唑啉杀虫剂的制备方法
摘要:本发明一种异噁唑啉杀虫剂的制备方法,涉及化工技术领域,包括如下步骤:1)偶联反应:将中间体1与硝基甲烷在溶剂中混合,再加入钯催化剂和配体进行催化偶联,反应后经分离纯化得到中间体2;2)关环反应:将中间体2和中间体3混合,并加入到脱水剂和碱的混合溶液中,充分关环反应,经纯化得到中间体4;3)缩合反应:将中间体4与中间体5混合,并加入缩合剂,充分缩合反应,经分离纯化得到异恶唑啉化合物6.本发明反应路线短,原料易得,三废较少,产物纯化后纯度高,适合工业化生产.

专利信息

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:WO-2024175691-A1
优先权日:2023-02-24
标题 :Process for the preparation of substituted chalcones
发明人：BOBNAR JERNEJ
权利人:KRKA D D NOVO MESTO
摘要:The invention relates to an improved process for the preparation of substituted chalcones using a base that plays double role in the process, as it removes free water and catalyzes aldol condensation. Consequently, the process is cost efficient and is easily scalable to industrial level. The substituted chalcones are useful intermediates in the synthesis of isoxazolines such as Fluralaner, Afoxolaner and Sarolaner, which are known systemic insecticides and acaricides.

专利号:US-11548859-B2
优先权日:2018-12-21
标 题 :Method for producing (5,S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4Hisoxazol-3-yl]-2-methyl-benzoic acid
发明人：SCHMITT HARALD
权利人:INTERVET INC
摘要:The present invention relates to a novel method for preparing (5S)-4-[5-(3,5-di-chlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid, which can preferably be used in the synthesis of (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoro-methyl)-4H-isoxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-2-methyl-benzamide.

专利号:US-11530187-B2
优先权日:2018-12-21
标 题 :Method for producing (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid
发明人：SCHMITT HARALD
权利人:INTERVET INC
摘要:The present invention relates to a novel method for preparing (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid, which can preferably be used in the synthesis of (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-2-methyl-benzamide.

专利号:US-2014350261-A1
优先权日:2011-11-08
标 题 :Method for catalytic asymmetric synthesis of optically active isoxazoline compound, and optically active isoxazoline compound

专利号:CN-113512007-A
优先权日:2021-08-20
标题 :Synthesis of Florana