CAS: 936353-84-3; (6-(4-Methylpiperazin-1-yl)Pyridin-3-yl)Boronic Acid

英文名称(6-(4-Methylpiperazin-1-yl)Pyridin-3-yl)Boronic Acid
中文名称(6-(4-甲基哌嗪-1-基)吡啶-3-基)硼酸
IUPAC名称(6-(4-methylpiperazin-1-yl)pyridin-3-yl)boronic acid
其它别名[6-(4-甲基哌嗪-1-yl)嘧啶-3-Yl]硼酸; Disodium [6-(4-Methylpiperazin-1-yl)-3-Pyridyl]-Dioxidoborane
CAS编号936353-84-3
MFCD编号:MFCD09907981
EINECS号:988-500-3
分子式:C10H16BN3O2
分子量:221.06
产品CID: 1976162
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: YGZOCDXCJWHNQN-UHFFFAOYSA-N
InChI=1S/C10H16BN3O2/c1-13-4-6-14(7-5-13)10-3-2-9(8-12-10)11(15)16/h2-3,8,15-16H,4-7H2,1H3…
计算化学: 氢键受体数5.0氢键供体数2.0可旋转键数2.0

相似化合物

918524-63-7 919347-67-4 1003043-67-1

物理性质

沸点432.5±55.0 °C at 760 mmHg
闪点215.4±31.5 °C
密度1.3±0.1 g/cm3
pKa:4.42±0.18(预测)
PSA:59.83
LogP:-1.4868
折射率1.596
蒸汽压0.0±1.1 mmHg at 25°C
外观形态白色至类白色固体
储存条件在惰性气体(氮气或氩气)下 2-8°C
产品应用该化合物用于合成一系列苯二烯基苯并呋喃衍生物,作为对肿瘤细胞线的抗扩散剂.

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼损伤类别1
警示词Danger(危险)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H318 |造成严重眼损伤.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

欧盟法规

C&L通报

合成工艺路线路线简述

109-01-3 + 444120-95-0 = 936353-84-3
反应条件:1.1 Reagents: Triethylamine Solvents: Dimethyl Sulfoxide; 12 H,90 °C1.2 Reagents: Water
标题:Piperidin-1-Yl-N-Pyridin-3-Yl-2-Oxoacetamide Derivatives Useful For The Treatment Of Mtap-Deficient And/or Mt-A Accumulating Cancers And Their Preparation
参考文献:World Intellectual Property Organization]

109-01-3 + 444120-94-9 = 936353-84-3
反应条件:1.1 Reagents: Diisopropylethylamine Solvents: N-Methyl-2-Pyrrolidone; 1.5 H,180 °C
标题:Preparation Of Pyridopyrazine Derivatives For Use As Syk Inhibitors
参考文献:World Intellectual Property Organization

海关参考信息

2921211000-乙二胺
2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.