CAS: 106-39-8; 1-Bromo-4-Chlorobenzene

上下游产品

bromobenzene ethanol 4-chlorophenyldiazonium salt 4-bromo-benzenediazonium ion para-chlorobenzoic acid 4-chlorodiphenyl ether 1,4-diphenoxybenzene para-dichlorobenzene

对氯苯胺置于亚硝酸特丁酯,四丁基溴化铵,Copper(I) Bromide,软骨素硫酸钠盐体系中,用 乙腈 用作溶剂,化学反应 24.0H,以61%的收率获得4-溴氯苯
参考文献:通过热稳定的樟脑磺酸樟脑磺酸盐进行卤代化和dna裂解
标题:通过热稳定的樟脑磺酸樟脑磺酸盐进行卤代化和dna裂解
摘要:在亚硝酸钠和樟脑磺酸存在下,通过几种芳族胺的简单重氮化反应,合成了一系列稳定的樟脑磺酸樟脑磺酸盐(2A-2J).所有新的芳基重氮樟脑磺酸盐,将其通过多核(1 H和13 C)NMR,Ir,Dsc和x射线衍射分析(图2E和2F中)为的分子结构提供明确的证据2E和2F.在溶剂和无溶剂条件下研究了这些盐在卤化反应中的有效应用,并评估了dna裂解活性.这些樟脑磺酸樟脑磺酸盐被认为是有效的dna裂解剂.
Doi:10.1016/j.Tet.2013.02.016

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-8058477-B2
优先权日:2006-03-21
标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
发明人：HARTWIG JOHN F; SHEN QILONG
权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE
摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

专利号:WO-2012153162-A1
优先权日:2011-05-12
标题 :Novel method for preparation of atovaquone
发明人：ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI ANURAG
权利人:LUPIN LTD; ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI ANURAG
摘要:Provided is a process of preparation of 2-[ trans ,-4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy- 1,4-naphthoquinone, i.e. Atovaquone [I] which is cost effective, green, and eco-friendly process, without separation of any diastereomers or geometric isomers of intermediates obtained during the reactions. Also provided is separation of ' cis ' and ' trans ' isomer of intermediates VI, VII and VIII through selective crystallization in an appropriate solvent. A method for converting 2-[ cis ,-4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone to 2-[ trans -4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-l,4-naphthoquinone in presence of Lewis/ Bronsted acid is also provided. A process for preparation of compound 2-(4-(4- chlorophenyl)- 1 -hydroxy cyclohexyl)-3,4-dihydronaphthalen- 1 (2H)-one [IV] comprising condensation of (1,2-dihydronaphthalen-4-yloxy)trimethylsilane [II] with 4-(4- chlorophenyl)cyclohexanone [III] in presence of Lewis acid in organic solvent. The invention also encompasses a highly efficient and atomeconomic process for synthesis of compound [III] i.e. 4-(4-chlorophenyl)cyclohexanone as well as a process for synthesis of 2-[ cis -4-(4'- chlorophenyl)cyclohexyl]-3-hydroxy-l,4-naphthoquinone. Further provided is a process for isomerization of cis- Atovaquone i.e. 2-[ cis -4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-l,4- naphthoquinone to tnms-Atovaquone i.e. 2-[ trans -4-(4'-chlorophenyl)cyclohexyl]-3- hydroxy- 1,4-naphthoquinone in presence of Lewis acid.

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-6465693-B2
优先权日:1998-02-26
标 题 :Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates
发明人：BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS O
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.

专利号:EP-1058678-B1
优先权日:1998-02-26
标 题:Metal-catalyzed arylations and vinylations of hydrazines, hydrazones, hydroxylamines and oximes
发明人：BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS OLIVER
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.