CAS: 3132-64-7; Epibromohydrin

上下游产品

CAS号6308-13-0 1-Propanol,2,3-... | CAS号106-89-8 环氧氯丙烷 | CAS号106-95-6 烯丙基溴 | CAS号96-21-9 1,3-二溴-2-丙醇 | CAS号96-13-9 2,3-二溴-1-丙醇 | CAS号56-81-5 甘油 | CAS号106835-64-7 4-(oxiran-2-ylm... | CAS号3663-82-9 2-羟甲基-1,4-苯并二恶烷 | CAS号38791-92-3 4-(2-环氧乙烷甲氧基)苯甲腈 | CAS号329722-31-8 5-Nitro-2-(oxir... | CAS号119-61-9 二苯甲酮 | CAS号583-04-0 苯甲酸烯丙酯 | CAS号119-53-9 2-羟基-2-苯基苯乙酮 | CAS号4704-77-2 3-溴-1,2-并二酚 | CAS号56718-70-8 3-[4-(2-甲氧基乙基)苯... | CAS号14437-88-8 (R)-1-溴-2,3-二羟基丙烷

1-Amino-3-Bromopropan-2-Ol置于aluminum Oxide,2-溴苯酚,Potassium Bromide,Sodium Sulfite体系中,用 正己烷,水 用作溶剂,化学反应 11.83H,以91%的收率获得环氧溴丙烷
参考文献:一种他莫昔芬药物中间体环氧溴丙烷的合成方法
标题:一种他莫昔芬药物中间体环氧溴丙烷的合成方法
摘要:一种他莫昔芬药物中间体环氧溴丙烷的合成方法,包括如下步骤:在安装有蒸馏装置的反应容器中,加入1-氨基-3-溴-丙醇5.6Mol,2-溴-苯酚溶液6.1-6.3Mol,溴化钾溶液800Ml,氧化铝2.56Mol,己烷700Ml,亚硫酸钠溶液300Ml,升高溶液温度至70-75°C,反应3-5H,降低溶液温度至50-55°C,控制搅拌速度110-150Rpm,回流90-110Min,降低溶液温度至10-13°C,静置2-5H,溶液分层,取出油层,盐溶液洗涤,乙腈洗涤,异丙醇洗涤,减压蒸馏,收集80-85oc的馏分,在硝基甲烷中重结晶,得晶体环氧溴丙烷.

专利信息

专利号:US-7759520-B2
优先权日:1996-11-27
标 题 :Synthesis of selective androgen receptor modulators
发明人：DALTON JAMES T; MILLER DUANE D; YIN DONGHUA; HE YALI
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.

专利号:US-6995284-B2
优先权日:2000-08-24
标题 :Synthesis of selective androgen receptor modulators
发明人：DALTON JAMES T; MILLER DUANE D; HE YALI; YIN DONGHUA
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.

专利号:US-8450365-B2
优先权日:2009-05-12
标 题 :Efficient synthesis of galanthamine
发明人：MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ
权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS
摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

专利号:US-6506915-B1
优先权日:2001-06-14
标 题 :Synthesis of coenzyme Q10 ubiquinone
发明人：WEST DANIEL DAVID
摘要:Processes for the stereospecific synthesis of coenzyme Q10, ubiquinone, are disclosed; a total synthetic procedure using geraniol as the starting material. The process of the invention results in high yields of isometrically pure ubiquinone. The synthetic coenzyme Q10 can be used as an antioxidant, a nutritional supplement and as a pharmaceutical in treating many conditions.

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-8153615-B2
优先权日:2005-06-10
标 题:Synthesis of glycerolipid carbamates and dicarbamates and their use as an antitumor compounds
发明人：BITTMAN ROBERT; BYUN HOE-SUP; ARTHUR GILBERT
权利人:BITTMAN ROBERT; BYUN HOE-SUP; ARTHUR GILBERT
摘要:The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.