CAS: 35543-24-9; 4-(Pyrrolidin-1-yl)-1-(2,4,6-Trimethoxyphenyl)Butan-1-One Hydrochloride

上下游产品

1,2,3-trimethoxybenzene 4-(pyrrolidin-1-yl)butanoyl chloride

1,3,5-三甲氧基苯,4-(Pyrrolidin-1-yl)Butanoyl Chloride置于zinc(II) Chloride,盐酸体系中,用 二氯甲烷,乙醇 作为反应溶剂,化学反应 3.0H,以60.2 G的收率获得产物4-(1-吡咯烷基)-1-(2,4,6-三甲氧基苯基)-1-丁酮盐酸盐
参考文献:盐酸丁咯地尔的制备方法
标题:盐酸丁咯地尔的制备方法
摘要:本发明盐酸丁咯地尔的制备方法涉及药物生产领域,具体涉及盐酸丁咯地尔的制备方法,包括以下步骤:L‑吡咯烷基丁酸甲酯的合成,在干燥反应瓶中投入68.3G4‑氯丁酸甲酯,无水碳酸钾82.8G,碘化钾0.2G,吡咯烷39.1G,丙酮500Ml,加热至回流反应3H后,将反应液冷却至室温后滤除碳酸钾,滤液减压至干后加入二氯甲烷500Ml溶解,再用饱和氯化铵水溶液洗涤有机相至ph为7~8,有机相经无水硫酸镁干燥后浓缩去除二氯甲烷得浓缩物,将浓缩物减压蒸馏收集107‑109度馏分得l‑吡咯烷基丁酸甲酯80.1G;本发明工艺简单,反应安全,合成路线短,原料易得,条件温和,成本更低廉.

专利信息

专利号:US-8088740-B2
优先权日:2009-05-04
标题:Gold binding peptides and shape-and size-tunable synthesis of gold nanostructures
发明人：HUR HOR GIL; KIM JUNG OK; KIM DAE HEE; MYUNG NO SANG
权利人:HUR HOR GIL; KIM JUNG OK; KIM DAE HEE; MYUNG NO SANG; KWANGJU INST SCI & TECH
摘要:The present invention relates to gold binding peptides and shape- and size-tunable synthesis of gold nanostructures. The present inventions are very useful for the production of well-designed, gold-based architectures. The size- and shape-specific gold nanostructure materials prepared by the present invention may find use as: highly conductive interconnections for single-electron transistors, catalysts for the oxidation of carbon monoxide; biological and chemical sensors; and as contrasting agents for electron microscopic and medical imaging applications.

专利号:US-11612610-B2
优先权日:2018-12-14
标题:Mito-magnolol compounds and methods of synthesis and use thereof
发明人：KALYANARAMAN BALARAMAN; ZIELONKA JACEK MICHAL; CHENG GANG; HARDY MICAEL JOËL; OUARI OLIVIER
权利人:MEDICAL COLLEGE WISCONSIN INC; AIX MARSEILLE UNIV; MEDICAL COLLEGE OF WISCONSIN INC
摘要:The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.

专利号:US-11897910-B2
优先权日:2015-06-11
标 题:Mito-honokiol compounds and methods of synthesis and use thereof
发明人：KALYANARAMAN BALARAMAN; ZIELONKA JACEK MICHAL; CHENG GANG; HARDY MICAEL J; OUARI OLIVIER; YOU MING
权利人:MEDICAL COLLEGE WISCONSIN INC; AIX MARSEILLE UNIV
摘要:The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.

专利号:WO-2020132738-A1
优先权日:2018-12-28
标 题:Resole phenolic resins, processes of synthesis of said resins and use thereof

专利号:US-2017203369-A1
优先权日:2014-07-11
标题 :Synthesis of uniform anisotropic nanoparticles

专利号:US-2010280220-A1
优先权日:2009-05-04
标题:Gold binding peptides and shape-and size-tunable synthesis of gold nanostructures