CAS: 499-08-1; 3-Fluoro-5-Nitrotoluene

上下游产品

CAS号618-61-1 3-甲基-5-硝基苯胺 | CAS号618-85-9 3,5-二硝基甲苯 | CAS号93857-90-0 3-氟-5-氯甲苯 | CAS号52215-41-5 3-氟-5-甲基苯胺 | CAS号66584-31-4 3-甲氧基-5-甲基苯胺

3,5-二硝基甲苯置于ammonium Polysulphide体系中,化学反应生成 3-氟-5-硝基甲苯
参考文献:氯化吡咯与一些取代的苯胺反应的动力学.第5部分
标题:氯化吡咯与一些取代的苯胺反应的动力学.第5部分
摘要:已测量了氯化吡咯与以下取代的苯胺在乙腈中的反应的arrhenius参数:3-氨基和3-甲基苯胺,3-氨基-5-硝基苯胺,3-氟-5-甲基磺酰基苯胺,3-X-5-甲基苯胺(x = No 2,Ome,Ch 3,F,Cl,Br或i)和3,5-X 2-苯胺(x = F,Cl,Br或i).现已研究了总共33个3,5-二取代苯胺对取代基对活化自由能的可加性的影响,并且表明,除3-氨基-5-硝基苯胺外,该假说重现了实验速率常数.在2分之一的范围内,当使用更严格的可加性标准时,对于某些情况下出现的偏差提出了合理化建议.
DOI:10.1039/p29800000829

专利信息

专利号:US-8129544-B2
优先权日:2002-10-15
标题:1-substituted-4-nitroimidazole compound and method for preparing the same
发明人：GOTO FUMITAKA; TAKEMURA NORIAKI; OTANI TADAAKI; HASEGAWA TAKESHI; TSUBOUCHI HIDETSUGU; UTSUMI NAOTO; FUJITA SHIGEKAZU; KURODA HIDEAKI; SHITSUTA TAKUYA; SASAKI HIROFUMI
权利人:GOTO FUMITAKA; TAKEMURA NORIAKI; OTANI TADAAKI; HASEGAWA TAKESHI; TSUBOUCHI HIDETSUGU; UTSUMI NAOTO; FUJITA SHIGEKAZU; KURODA HIDEAKI; SHITSUTA TAKUYA; SASAKI HIROFUMI; OTSUKA PHARMA CO LTD
摘要:The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, n n(wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula —CH 2 R A ; X is a halogen atom or a group of the formula —S(O)n-R 1 ) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.