CAS: 5459-58-5; Butyl Cyanoacetate

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CAS号372-09-8 氰基乙酸 | CAS号71-36-3 正丁醇 | CAS号109-77-3 丙二腈 | CAS号109-65-9 正溴丁烷 | CAS号590-02-3 氯乙酸丁酯 | CAS号143-33-9 氰化钠 | CAS号105-56-6 氰乙酸乙酯 | CAS号10412-93-8 N-苄基-2-氰基乙酰胺 | CAS号71-36-3 正丁醇 | CAS号107-91-5 氰乙酰胺 | CAS号6606-65-1 恩布酯 | CAS号80677-63-0 butyl 2-cyano-3...

氰乙酸置于zinc Perchlorate,Magnesium Sulfate体系中,用 正丁醇 作为反应溶剂,以77%的收率获得产物氰乙酸正丁酯
参考文献:使用代表性模型洞察偶氮和乙炔的等电特性:光谱和电化学研究
标题:使用代表性模型洞察偶氮和乙炔的等电特性:光谱和电化学研究
摘要:制备了一系列的偶氮甲碱和亚乙烯基二联体和三联体类似物.使用密度泛函理论(dft)计算,从实验和理论上检查了它们的吸光度,荧光和氧化还原特性.进行这些测量以确定偶氮甲碱的杂原子相对于其全碳对应物的作用,并评估两个键的等电特性.发现偶氮甲碱的取向对吸光度,荧光和电化学性质几乎没有影响.相反,光谱和电化学性质高度依赖于电子基团和共轭程度.可以将可见光区域的光谱特性调整为200 Nm.更重要的是,发现共轭键中的杂原子仅在吸光度和荧光光谱中产生20 Nm的红移.荧光量子产率(φ亚乙烯基衍生物的f1)在5%至20%之间变化,通过从e到z异构体的光异构化发生荧光猝灭.相反,类似的偶氮甲碱衍生物的荧光被完全猝灭.集体光谱和电化学从头算dft数据另外证实了偶氮甲碱及其类似的亚乙烯基是等电子的.还发现可以制备和分离在α,α'-位具有伯胺的共轭噻吩亚乙烯基二单元.如果有吸电子基团(酯基或腈基)位于相邻位置,则该化合物在有氧条件下是稳定的.
DOI:10.1021/jo401497Z

专利信息

专利号:US-4284582-A
优先权日:1978-04-28
标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides
发明人：KAYE ALBERT E; TUCKER ALAN C
权利人:ICI LTD
摘要:Compounds of formula: wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is -CN or -COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: wherein X1 is chlorine or bromine, with a compound of the formula: X2C=CH-CH=C(CH3)2 in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula: Y-CH2-CN with a compound of the formula: X2C=CH-CH=C(CH3)2 and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula: X-CH2-CN with a compound of the formula: wherein X1 is chlorine or bromine, in the presence of at least one copper salt. The compounds are intermediates in the synthesis of pyrethroid insecticides.

专利号:US-6933388-B2
优先权日:2003-04-09
标题:Process for the synthesis of 3-cyano-6-alkoxy-7-nitro-4-quinolones
发明人：DUNCAN SCOTT MASON; PAGAN MIGUEL ANGEL; FLOYD JR MIDDLETON BRAWNER
权利人:WYETH CORP
摘要:There is provided a process for the preparation of 3-cyano-6-alkoxy-7-nitro-4-quinolone intermediates useful for the preparation of protein tyrosine kinase (PTK) inhibitors which are useful in the treatment of cancer of the formula: n n nwherein R is alkyl(C 1 -C 3 ) prepared by reacting a substituted anthranilate with N,N-dimethylformamide dimethyacetal to obtain a N,N-dimethylamidine which is condensed with t-butylcyanoacetate to obtain a N-(2-cyano-2-t-butoxycarbonylvinyl)anthranilate, which is hydrolyzed to yield a N-(2-cyano-2-carboxyvinyl)anthranilate followed by decarboxylating to obtain a N-(2-cyano-2-carboxyvinyl)anthranilate followed by cyclizing to obtain a 3-cyano-6-alkoxy-7-nitro-4-quinolone.

专利号:WO-2011114184-A1
优先权日:2010-03-15
标题 :Amides of heterocyclic compounds as trpa1 inhibitors
发明人：CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; WAGHMARE NAYAN TATERAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
权利人:GLENMARK PHARMACEUTICALS SA; CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; WAGHMARE NAYAN TATERAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
摘要:Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/ or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I).

专利号:US-9670145-B2
优先权日:2014-03-31
标题:Process for preparing 1,1-disubstituted ethylene monomers
发明人：TCHAPLINSKI VLADIMIR; GHERARDI STEFANO; DE LA FUENTE MOLINA VERÓNICA
权利人:AFINITICA TECH S L
摘要:The present invention relates to a process for preparing 1,1-disubstituted ethylene monomers having general formula (I) from a compound of general formula (II) and an active methylene compound of general formula (III) using a catalytic amount of an ammonium or iminium a salt in homogeneous phase or supported on a solid substrate. Said process allows the direct synthesis of the monomers and finds application in the preparation of a wide variety of monomers. The products obtained are reactive monomers of high purity which find application in the field of fast curing adhesives.

专利号:US-8420805-B2
优先权日:2007-03-30
标题 :Process for preparing prophyrin derivatives, such as protoprophyrin (IX) and synthesis intermediates
发明人：MARTIN PIERRE; MUELLER MARKUS; SPIELVOGEL DIRK; FLUBACHER DIETMAR; BOUDIER ANDREAS
权利人:MARTIN PIERRE; MUELLER MARKUS; SPIELVOGEL DIRK; FLUBACHER DIETMAR; BOUDIER ANDREAS; SANOFI PASTEUR S A
摘要:The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: n nin which:n R and R′ are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): nn nin which R′b is as defined above for (I),n and a dipyrromethane of formula (III): nn nin which R″ is as defined in claim 1 , and also the compounds of formula (III).

专利号:EP-0007154-B1
优先权日:1978-04-28
标题:Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides