CAS: 5952-92-1; 1-Methyl-1H-Pyrazole-4-Carboxylic Acid

相似化合物

288083-62-5 401647-24-3 25016-11-9

上下游产品

CAS号85290-80-8 1-甲基吡唑-4-羧酸乙酯 | CAS号25016-11-9 1-甲基-1H-吡唑-4-甲醛 | CAS号1072-68-0 1,4-二甲基吡唑 | CAS号15803-02-8 4-溴-1-甲基-1H-吡唑 | CAS号109-72-8 正丁基锂 | CAS号60-29-7 乙醚 | CAS号591-51-5 苯基锂 | CAS号37687-18-6 1-(1-甲基-1H-吡唑-4-基)乙酮 | CAS号79583-19-0 1-甲基-1H-吡唑-4-羰酰氯 | CAS号1174064-57-3 4-Is°Cyanato-1-... | CAS号706819-66-1 2-溴-1-(1-甲基-1H-... | CAS号5952-93-2 1-甲基-1H-吡唑-4-羧酸甲酯

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于sodium Hydroxide,Potassium Permanganate体系中,化学反应生成 1-甲基吡唑-4-羧酸
参考文献:Huettel; Schoen,Justus Liebigs Annalen Der Chemie,1959,Vol. 625,P. 55,60
标题:Huettel; Schoen,Justus Liebigs Annalen Der Chemie,1959,Vol. 625,P. 55,60

专利信息

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:CN-117447401-A
优先权日:2023-12-26
标题:A kind of synthesis method of difluoropyrazole acid