CAS: 601-34-3; Cholesteryl Palmitate
该化合物是一种该化合物是一种白色,蜡状固体,熔点高,通常用于脂质研究,制药配方和化妆品应用.作为一种非极性脂,它与防水基体具有极强的稳定性和兼容性,因此适合受控释放药物运载系统和脂质外体.它的化学不高性和低再活性确保长期储存稳定性.在化妆品中,棕榈树胆固醇作为感化和厚质剂,可以增强质质质和粘性.由于化合物的特性明确,该化合物还被用作脂质特征分析的标准色谱分析.
- 英文名称Cholesteryl Palmitate
- 中文名称胆固醇棕榈酸酯
- IUPAC名称(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl palmitate
- 其它别名5-Cholestene 3-palmitate; Cholest-5-ene-3-beta-yl palmitate
- CAS编号601-34-3
- MFCD编号:MFCD00003638
- EINECS号:210-002-5
- FDA UNII编号:ZR4D53AD57
- 分子式:C43H76O2
- 分子量:625.06
- 产品CID: 1578046
- 产品分类化学试剂 → 有机试剂 → 酯类
物理性质
MSDS等安全信息
上下游产品
CAS号57-88-5 胆固醇 | CAS号57-10-3 棕榈酸 | CAS号112-67-4 棕榈酰氯 | CAS号555-44-2 (三)棕榈酸甘油酯合成工艺路线路线简述
- 合成目标产物 Cholesteryl Palmitate 主要起始原料 Cholesterol And Palmitoyl Chloride
- (文献来源)合成步骤主要原料 Cholesterol 和 Palmitoyl Chloride
棕榈酸置于氯化亚砜体系中,用 苯 作为反应溶剂,化学反应 4.0H,反应生成 胆固醇棕榈酸酯
参考文献:鱼肝中呋喃脂肪酸的完整胆固醇酯分析.
标题:鱼肝中呋喃脂肪酸的完整胆固醇酯分析.
摘要:呋喃脂肪酸(f-酸)是一类天然抗氧化剂,在酰基链中具有呋喃部分.据报道,这些次要脂肪酸在鱼肝的胆固醇酯部分中以高比例存在.在这里,我们提出了一种直接分析完整的胆固醇酯与鳕鱼肝脂质中的f-酸和其他脂肪酸的方法.为此,通过固相萃取(spe)分离胆固醇酯馏分,然后使用柱上冷却入口通过气相色谱质谱分析(gc / Ms)进行分析.用胆固醇酯化的十五烷酸用作内标.f-酸胆固醇酯的gc / Ms光谱显示了胆固醇和f-酸部分的分子离子以及特征性碎片离子.所有研究的鳕鱼肝样本(n = 8)均显示f-酸的胆甾醇酯,以及较低程度的常规脂肪酸.通过gc / Ms-Sim,样品中最多可以测定十种f-酸胆固醇酯.胆甾醇酸酯与常规脂肪酸的浓度总计为78-140 Mg / 100 G脂质(平均97 Mg / 100 G脂质),而f-酸胆甾醇酯的含量为47-270 Mg / 100 G脂质(平均130 Mg / 100克脂质).
DOI:10.1007/s11745-015-4019-7
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专利信息
专利号:WO-2025217610-A1
优先权日:2024-04-12
标题:Systems and methods for enzymatic oligonucleotide synthesis
发明人：ENTWISTLE DAVID; GAUNTLETT DEREK; MILLER MICHAEL; REEVES RYAN; WATTS DAVID
权利人:CODEXIS INC
摘要:The present invention provides for methods and systems for template-free synthesis of an oligonucleotide, and methods of using the systems as disclosed herein for template-free synthesis of an oligonucleotide.
专利号:DE-69332353-T2
优先权日:1992-07-24
标 题 :USE OF INHIBITORS OF THE SYNTHESIS OF FATTY ACIDS FOR THE TREATMENT OF CANCER
专利号:US-5759837-A
优先权日:1989-01-17
标题:Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
发明人：KUHAJDA FRANCIS P; PASTERNACK GARY R
权利人:UNIV JOHNS HOPKINS
摘要:Fatty acid synthase (FAS) is overexpressed in carcinomas with poor prognosis, but little FAS expression is identified in normal tissues Inhibition of fatty acid synthesis is selectively toxic to carcinoma cells, while normal cells with low FAS activity are resistant. This invention provides a method of treating cancer patients where fatty acid synthesis by cells of the patient's tumor is inhibited with resultant interruption of the disease process.
专利号:EP-0651636-B1
优先权日:1992-07-24
标 题 :Chemotherapy for cancer
发明人：KUHAJDA FRANCIS P; PASTERNACK GARY R
权利人:UNIV JOHNS HOPKINS
摘要:Fatty acid synthase (FAS) is overexpressed in carcinomas with poor prognosis, but little FAS expression is identified in normal tissues. Inhibition of fatty acid synthesis is selectively toxic to carcinoma cells, while normal cells with low FAS activity are resistant. This invention provides a method of treating cancer patients where fatty acid synthesis by cells of the patient's tumor is inhibited with resultant interruption of the disease process.
专利号:AU-4786493-A
优先权日:1992-07-24
标题 :Use of inhibitors of fatty acid synthesis for treating cancer
专利号:CA-1117041-A
优先权日:1978-10-24
标 题 :Lipoproteic complex stabilizing the effect of vitamin e and synthesis antioxidants
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主要参考文献
1. Shine, W.E., and McCulley, J.P. Polar lipids in human meibomian gland secretions. Curr. Eye Res. 26(2), 89-94 (2003). 2. Ludmir, J., Alvarez, J.G., Mennuti, M.T., et al. Cholesteryl palmitate as a predictor of fetal lung maturity. Am. J. Obstet. Gynecol. 157(1), 84-88 (1987). 3. Ludmir, J., Alvarez, J.G., Landon, M.B., et al. Amniotic fluid cholesteryl palmitate in pregnancies complicated by diabetes mellitus. Obstet. Gynecol. 73(3 Pt.1), 360-362 (1988). 4. Fukuhara, N., Tachihara, M., Tanino, Y., et al. Cholesteryl palmitate crystals in bronchoalveolar lavage fluid smears as a possible prognostic biomarker for chronic interstitial pneumonia: A preliminary study. Respir. Investig. 54(2), 109-115 (2016).合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.1007/pl00000925
摘要:Batetta B, Mulas MF, Petruzzo P, Putzolu M, Bonatesta RR, Sanna F, Cappai A, Brotzu G, Dessì S. Opposite pattern of MDR1 and caveolin-1 gene expression in human atherosclerotic lesions and proliferating human smooth muscle cells. Cellular and Molecular Life Sciences. 2001 Jul;58(8):1113–20. doi: 10.1007/pl00000925.
参考文献:10.1007/s13346-017-0360-0
摘要:Rambharose S, Kalhapure RS, Jadhav M, Govender T. Exploring unsaturated fatty acid cholesteryl esters as transdermal permeation enhancers. Drug Delivery and Translational Research. 2017 Feb 03;7(2):333–45. doi: 10.1007/s13346-017-0360-0.
参考文献:10.1038/s42003-022-03154-w
摘要:Inoue T, Kuwano T, Uehara Y, Yano M, Oya N, Takada N, Tanaka S, Ueda Y, Hachiya A, Takahashi Y, Ota N, Murase T. Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids. Communications Biology. 2022 Mar 09;5(1):215. doi: 10.1038/s42003-022-03154-w.
参考文献:10.1074/jbc.272.7.3980
摘要:Yang H, Cromley D, Wang H, Billheimer JT, Sturley SL. Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity. J Biol Chem. 1997 Feb 14;272(7):3980–5. doi: 10.1074/jbc.272.7.3980.
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