CAS: 69-53-4; Ampicillin

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CAS号551-16-6 6-氨基青霉烷酸 | CAS号700-63-0 DL-苯基甘氨酰胺 | CAS号24461-61-8 methyl (R)-amin... | CAS号3412-49-5 (R)-4-苯基氧氮杂环戊烷-... | CAS号19883-41-1 D-苯甘氨酸甲酯盐酸盐 | CAS号15028-40-7 甲基-2-氨基-2-苯乙酸酯盐酸盐 | CAS号33817-20-8 匹凡西林 | CAS号37661-08-8 盐酸巴氨西林 | CAS号37091-66-0 阿洛西林 | CAS号551-16-6 6-氨基青霉烷酸 | CAS号875-74-1 D-(-)-α-苯基甘氨酸 | CAS号47747-56-8 酞氨西林 | CAS号51481-65-3 美洛西林 | CAS号61-33-6 青霉素 | CAS号1252608-05-1 2-formyl-5,5-di... | CAS号611-73-4 苯甲酰甲酸

6-氨基青霉烷酸置于甲基2-(苯基氨基)乙酸酯体系中,用 乙二醇 作为反应溶剂,化学反应 48.0H,以96.7%的收率获得产物氨苄西林
参考文献:磁性可分离固定化青霉素g酰基转移酶高效合成氨苄西林.
标题:磁性可分离固定化青霉素g酰基转移酶高效合成氨苄西林.
摘要:青霉素g酰基转移酶(pga)被固定在磁性亲水聚合物微球上,其平均孔径为17.1Nm,比表面积为128.2M 2 / G,饱和磁化强度为6.4Emu / G.使用6-氨基青霉酸(6-Apa)和d-(-)-α-苯基甘氨酸甲酯(d-Pgme),合成/水解(s / H)比为1.60的氨苄青霉素可达到96.7%.得到的磁性生物催化剂在乙二醇中,在相同的反应条件下使用游离pga仅能获得82.1%的收率和1.40的s / H比.固定的pga可以通过磁力分离并循环使用五次,而不会明显降低其催化活性.
DOI:10.1016/j.Cclet.2010.02.015

专利信息

专利号:US-2025019732-A1
优先权日:2023-07-07
标 题:Method for chemical-biological cascade synthesis of l-phosphinothricin and mutants therefor
发明人：XUE YAPING; CHENG FENG; ZOU SHUPING; XU JIANMIAO; ZHENG YUGUO
权利人:UNIV ZHEJIANG TECHNOLOGY
摘要:A method for chemical-biological cascade synthesis of L-phosphinothricin is carried out as follows: 3-(methylethoxyphosphinyl) ethyl propionate is synthesized by addition reaction from diethoxymethylphosphine and acrylic acid, then a condensation reaction is carried out with 3-(methylethoxyphosphinyl) ethyl propionate and sodium ethoxide as reactants, then the product is subjected to a hydrolysis reaction with diethyl oxalate to synthesize 4-(hydroxymethylphosphinyl)-2-oxobutyric acid, and finally, L-phosphinothricin is catalytically synthesized by taking 4-(hydroxymethylphosphinyl)-2-oxobutyric acid as a raw material, and using highly active and stable wet cells co-expressing phsophinothricin dehydrogenase and alcohol dehydrogenase or co-expressing a phsophinothricin dehydrogenase mutant and alcohol dehydrogenase as a biocatalyst, thereby solving the problems of existing L-phosphinothricin synthesis being tedious, low asymmetric amination reduction activity and poor stability.

专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人：KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:EP-2173892-B8
优先权日:2007-07-27
标题:Process for the preparation of immobilised recombinant Penicillin Acylase biocatalyst from Achromobacter sp CCM 4824 expressed in E. coli BL21 CCM 7394 and its use for the synthesis of beta-lactam antiobiotics
发明人：DATLA ANUPAMA; RAJASEKAR VYASARAYANI WILLIAMS; KYSLIK PAVEL; BECKA STANISLAV; KRISHNAKANT ASHAR TRUPTI; YOGESH ZAMBRE SUJATA; NIKUNJ KUMAR
权利人:FERMENTA BIOTECH LTD
摘要:The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIP1 and processing of PA into biocatalyst useful for the industrial synthesis of antibiotics. More particularly the invention discloses a synthesis of semi-synthetic β-lactam antibiotics in the reaction mixture consisting of activated acyl-donor (D-p-hydroxyphenylglycine methyl ester or amide for Amoxicillin and Cefadroxil; D-phenylglycine methyl ester or amide for Ampicillin and Cephalexin) and nucleophile (6-APA or 7-ADCA) catalyzed by PA obtained from recombinant E. coli BL21 CCM 7394 as the biocatalyst.

专利号:WO-9010069-A1
优先权日:1989-02-28
标题:RECOMBINANT PLASMID DNA pAA 1213-23 AND pAC 262-33 CODING FOR SYNTHESIS OF HUMAN INTERLEUKIN-2, METHOD OF THEIR CONSTRUCTION AND STRAIN OF BACTERIA ESCHERICHIA COLI RRI/pAC 262-33 AS PRODUCER OF HUMAN INTERLEUKIN-2
发明人：AVOT ANDRIS YANOVICH; VARIVOTSKAYA NADEZHDA VIKTOROV; VOITENOK NIKOLAI NIKOLAEVICH; GREN ELMAR YANOVICH; MARTINOVICH ALEXANDR EVGENIEVI; ROMANCHIKOVA NADEZHDA VIKTOROV; SEVCH NINA VYACHESLAVOVNA; TSIMANIS ALEXANDR JURIEVICH; APSALON ULDIS RUDOLFOVICH; BUNDULIS JURIS PETROVICH; LUNEV VITALY EVGENIEVICH; ONOPRIENKO LJUDMILA VIKTOROVNA; SKRIVELIS VITALY ANDRISOVICH
权利人:INST ORGANICHESKOGO SINTEZA AK
摘要:A recombinant plasmid DNA pAA 1213-23 coding for synthesis of human interleukin-2 has a size of 5,150 b.p. and consists of the following elements: an EcoRI-SalI fragment, of a size of 3,710 b.p. of vector plasmid pBR 322; a Cfr 13 fragment of a size of 880 b.p. containing a promoter of tryptophan operon, a polylinker section of recognition of restrictase EcoRI, SmaI, BamHI, initiating ATG and first GCC codons of mature interleukin-2; a Cfr 13-SalI fragment of a size of 570 b.p. of cloned cDNA. A recombinant plasmid DNA pAC 262-33 on the basis of said DNA pAA 1213-23 has a size of 5,135 b.p. and consists of the following elements: an EcoRI-SalI fragment of a size of 3,710 b.p. of vector plasmid pBR 322; a Cfr 13 fragment of a size of 867 b.p.; a Cfr 13-SalI fragment of a size of 570 b.p. of cloned cDNA. A method of construction of recombinant plasmid DNA pAC 262-33 comprises the preliminary construction of plasmid DNA pAA 1213-23 with subsequent construction, on its basis, of plasmid pAC 262-33 with a changed distance between the Shine-Dalgarno sequence and the initiating ATG codon. A strain Escherichia coli RRI/pAC 262-33 as producer of interleukin-2 deposited on 10.07.87 under No VKPM B-3823 at the USSR-Union Collection of Industrial Microorganisms of the USSR Research Institute for Genetics and Industrial Microorganisms Breeding.

专利号:US-7402418-B2
优先权日:2001-09-20
标 题:Genes participating in the synthesis of fatty acid having trans-11-,cis-13-conjugated double bond and utilization thereof
发明人：OSUMI MARI; MURASE JUNKO; IMAMURA JUN
权利人:PLANTECH RES INST; INC ADMIN AGENCY NARO
摘要:An object of the present invention is to clone a gene which is involved in synthesis of fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bone at position Δ12. The present invention provides a gene having any one of the following nucleotide sequences:n (A) a nucleotide sequence encoding an amino acid sequence shown in SEQ ID NO: 1 or 12; (B) a nucleotide sequence encoding an amino acid sequence comprising a deletion, addition or substitution of one or several amino acids with respect to the amino acid sequence shown in SEQ NO: 1 or 12, and having an ability of synthesizing fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bond at position Δ12; (C) a nucleotide sequence shown in SEQ ID NO: 2 or 13; (D) a nucleotide sequence comprising a deletion, addition or substitution of one or several nucleotides with respect to the nucleotide sequence shown in SEQ ID NO: 2 or 13, and encoding a protein having an ability of synthesizing fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bond at position Δ12; and (E) a nucleotide sequence hybridizing with the nucleotide sequence shown in SEQ ID NO: 2 or 13 or a complementary sequence thereof under stringent conditions, and encoding a protein having an ability of synthesizing fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bond at position Δ12.

专利号:US-2005186197-A1
优先权日:2002-08-29
标 题:Peptide inhibitors of beta lactamases
发明人：PALZKILL TIMOTHY; HUANG WANZHI
摘要:Peptide inhibitors of β-lactamases have been identified by the synthesis of peptide arrays using synthesis SPOT technology. These peptide inhibitors of β-lactamase have activity against a broad spectrum of β-lactamases and are useful in a variety of applications.