专利号:US-9469614-B2 优先权日:2011-10-27 标 题:Synthesis of triazolopyrimidine compounds 发明人:ZUPANCIC BORUT; MARAS NENAD; STERK DAMJAN 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.
专利号:EP-2586773-A1 优先权日:2011-10-27 标题 :Synthesis of Triazolopyrimidine Compounds 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.
专利号:US-7605290-B2 优先权日:2006-07-26 标题 :Processes for the synthesis of O-desmethylvenlafaxine 发明人:NIDDAM-HILDESHEIM VALERIE; SHENKAR NATALIA; SHACHAN-TOV SHARONA 权利人:TEVA PHARMA 摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.
专利号:US-2009069601-A1 优先权日:2006-07-26 标题:Processes for the synthesis of O-desmethylvenlafaxine 发明人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION 权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION 摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.
专利号:US-5215997-A 优先权日:1985-09-11 标题:Synthesis of beta-lactam compounds 发明人:HUNGERBUEHLER ERNST; KALVODA JAROSLAV 权利人:CIBA GEIGY CORP 摘要:The invention relates to an improved process for the preparation of compounds of formula ##STR1## or salts thereof, starting from compounds of formulae ##STR2## via compounds of formulae ##STR3## in which compounds R 1 is hydrogen or lower alkyl, R 2 is an organic radical which may carry a functional group which may be protected by a customary protective group R 2 o , R 3 is hydrogen or a customary carboxyl protective group R 3 o , W is a group which can be replaced by a thiocarboxylic acid radical of formula III, and Z is oxygen or sulfur.
专利号:US-2008221356-A1 优先权日:2006-07-26 标题:Processes for the synthesis of O-desmethylvenlafaxine 发明人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION 权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION 摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.
[参考文献]: Maryam Goudarzi, Et Al. The Effect Of Low Dose Rate On Metabolomic Response To Radiation In Mice. Radiat Environ Biophys. 2014 Nov;53(4):645-57.
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