CAS: 710-18-9; 1-Methoxy-4-(Trifluoromethoxy)Benzene

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CAS号70744-47-7 三丁基-(4-甲氧基-苯基)-锡烷 | CAS号96898-10-1 trifluoromethan... | CAS号5720-07-0 4-甲氧基苯硼酸 | CAS号56-23-5 四氯化碳 | CAS号150-76-5 4-甲氧基苯酚(MEHQ) | CAS号877-68-9 4-(三甲基甲硅烷基)苯甲醚 | CAS号828-27-3 4-三氟甲氧基苯酚 | CAS号290832-43-8 2-甲氧基-5-(三氟甲氧基)苯基硼酸 | CAS号145742-65-0 2-甲氧基-5-(三氟甲氧基)苯甲醛 | CAS号191604-88-3 2-甲氧基-5-(三氟甲氧基)苯甲酸 | CAS号660848-57-7 2-甲氧基-5-(三氟甲氧基)苯胺

对三氟甲氧基苯酚,3-Bromophenyltrimethylammonium Iodide置于potassium Carbonate体系中,用 二甲基亚砜 作为反应溶剂,化学反应 3.0H,以21%的收率获得产物4-(三氟甲氧基)苯甲醚
参考文献:三烷基铵盐的降解:对甲基化和交叉偶联的影响
标题:三烷基铵盐的降解:对甲基化和交叉偶联的影响
摘要:已知三烷基铵(最显着的是n,N,N-三甲基苯铵)盐通过芳基和n-甲基均显示出双重反应性.因此,这些盐已广泛应用于交叉偶联,芳基醚化,氟放射性标记,相转移催化,超分子识别,聚合物设计和(最近)甲基化.然而,它们作为亲电甲基化试剂的应用仍未得到充分开发,并且缺乏对它们的芳基化与甲基化反应性的了解.本研究提出了n,N,N的机械降解分析.-三甲基苯胺盐,并突出了这一重要类别盐对合成应用的意义.在固相和固溶阶段的动力学降解研究已经深入了解了影响苯胺盐稳定性的物理和化学参数.盐降解的1 H NMR动力学分析表明,热降解为甲基碘和母体苯胺,与闭壳s N一致2位降解途径,而甲基碘是应用甲基化程序中的关键反应物种.此外,还研究了卤化物和非亲核抗衡离子对盐降解的影响,以及氘同位素和溶剂的影响.新的力学见解使人们能够研究三甲基苯胺盐在o-甲基化中的应用以及在改进的交叉偶联策略中的应用.最后,详细的计算研究有助于
DOI:10.1039/d1Sc00757B

专利信息

专利号:US-4446078-A
优先权日:1982-01-21
标 题 :Process for the preparation of α,α-difluoroalkyl-thiophenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of alpha , alpha -difluoroalkoxy or alpha , alpha -difluoroalkylthiophenyl ketones, in which a polyhaloalkoxybenzene or a polyhaloalkylthiobenzene is reacted with a carboxylic acid, a precursor or a derivative of this acid in the presence of boron trifluoride in such an amount that the absolute pressure of the boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent. The resultant products are useful as intermediates in the synthesis of compounds having phytosanitary (e.g., herbicidal) or pharmaceutical activity.

专利号:US-4552984-A
优先权日:1982-01-21
标题 :Process for preparation of α,α-difluoroalkoxy or α,.alpha.
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of alpha , alpha -difluoroalkoxy or alpha , alpha -difluoroalkylthiophenyl sulfones, in which a polyhaloalkoxybenzene or a polyhaloalkylthiobenzene is reacted with a sulfonic acid, a derivative or a precursor of this acid, in the presence of boron trifluoride in an amount such that the absolute pressure of the boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent. The resultant products are useful as intermediates in the synthesis of compounds having a phytosanitary (e.g., herbicidal) or pharmaceutical activity.

专利号:US-4438043-A
优先权日:1982-04-22
标题:Process for preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones, characterized in that, in a first stage, a di- or trihalomethoxybenzene or a di- or trihalomethylthiobenzene is reacted with a trihalomethylated aromatic or aliphatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent and in that, in a second stage, the product of the first stage is hydrolyzed. The resultant products are useful as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-9169209-B2
优先权日:2011-05-04
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and composition for inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.