CAS: 10025-87-3; Phosphorus Oxychloride

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CAS号10026-13-8 五氯化磷 | CAS号2449-19-6 Boronic acid, 1... | CAS号7330-44-1 dibutoxy-(3-dib... | CAS号2696-92-6 亚硝酰氯 | CAS号14700-20-0 trihydroxy(imin... | CAS号80937-33-3 oxygen | CAS号7719-12-2 三氯化磷 | CAS号57514-99-5 phosphoryl(V)-t... | CAS号1858-25-9 Phosphorothioic... | CAS号7719-09-7 氧氯化硫 | CAS号107112-93-6 6,7-Dihydrothie... | CAS号14807-82-0 propan-1-ol 2-p... | CAS号10602-14-9 2-hydroxypropyl... | CAS号10470-77-6 Acetic acid, 2-... | CAS号7439-52-3 bis(4-dimethyla... | CAS号101-61-1 4,4'-四甲基二氨基二苯甲烷 | CAS号1104-21-8 Benzenamine,4,4... | CAS号105728-76-5 (4-bromophenyl)... | CAS号491-45-2 藤黄盐 | CAS号4979-79-7 4-氯-2-苯基喹啉

甲基膦酸二甲酯置于五氯化磷体系中,用 二氯甲烷 用作溶剂,化学反应 0.5H,以43 G的收率获得三氯氧磷
参考文献:烷基氯化膦酸单烷酯联产高纯度三氯氧磷的方法
标题:烷基氯化膦酸单烷酯联产高纯度三氯氧磷的方法
摘要:本发明公开了一种烷基氯化膦酸单烷酯联产高纯度三氯氧磷的方法,包括以下步骤:(1)将五氯化磷和烷基膦酸二烷酯在溶剂中进行反应,得到含有溶剂的烷基氯化膦酸单烷酯和三氯氧磷的混合物;反应过程中生成气相一氯甲烷或一氯乙烷;(2)对反应中产生的气相一氯甲烷或一氯乙烷,溶剂,烷基氯化膦酸单烷酯及三氯氧磷分别分离回收.本发明是用五氯化磷和烷基膦酸二烷酯反应制备烷基氯化膦酸单烷酯同时,产生了大量的三氯氧磷和溶剂的混合物,找到了合适的回收方法,联产高纯度的三氯氧磷,可获得较好的经济效益,同时减少了三废的排放.

专利信息

专利号:WO-2024185734-A1
优先权日:2023-03-03
标 题:Polyphosphorylated nucleoside, phosphate-activated nucleotide used for synthesis of polyphosphorylated nucleoside and method for synthesis of same, and method for synthesis of polyphosphorylated nucleoside using phosphate-activated nucleotide
发明人：KATAOKA MASANORI; FUKUI CHIHARU; TSUJI YOHEI; FUJIMURA Kazuma
权利人:NATIAS INC
摘要:The present invention provides: a polyphosphorylated nucleoside which has a structure represented by formula (I) and can be efficiently produced by a short process and a simple operation with use of a less expensive material; a phosphate-activated nucleotide which is used for the synthesis of the polyphosphorylated nucleoside and a method for the synthesis of this phosphate-activated nucleotide; and a method for the synthesis of a polyphosphorylated nucleoside using a phosphate-activated nucleotide. In the formula, B represents a protected or unprotected, natural or artificial nucleoside base; R 1 , R 2 , R 4 and R 5 each represent H or an alkyl group or the like, and R 1 , R 2 , R 4 and R 5 may be the same as or different from each other; X and Y each represents H, OH, OCH 3 or the like; h represents an integer of 1 to 3; p, n, m and q each represent 0 or an integer, and p, n, m and q are in no particular order; and (p + n + m + q) is an integer of 0 to 5,000.

专利号:US-4399069-A
优先权日:1980-10-12
标题:Process for an enantioselective synthesis of optically active 14-oxo-E-homo-eburnane derivatives
发明人：SZANTAY CSABA; SZABO LAJOS; KALAUS GYORGY; SAPI JANOS; KREIDL JANOS; FARKAS NEE KIRJAK MARIA; NEMES ANDRAS; CIBULA LASZLO
权利人:RICHTER GEDEON VEGYESZET
摘要:The invention relates to a new enantioselective synthesis for the preparation of optically active 14-oxo-E-homo-eburnane derivatives of the formula (Ia) ##STR1## wherein R 1 is alkyl having from 1 to 4 carbon atom. In the synthesis optically active 6-alkoxycarbonylhexahydroindoloquinolizinium salts are employed as starting materials, which contain a center of chirality at the site of attachment of the carboxyl group. This center of chirality preserves the optical activity of the optically active tryptophan ester from which this compound has been prepared until a new center of chirality is formed in the molecule in a configuration corresponding to the desired end product. The carboxyl group, which is not needed in the end product and only serves to preserving the optical activity can then be eliminated. n Compounds of the formula (Ia) are known in the art and may be used in the synthesis of (+)-vincamine and (+)-apovincaminic acid ethylester.

专利号:US-5523434-A
优先权日:1995-03-15
标 题 :Synthesis of bleach activators
发明人：BURNS MICHAEL E; SIMPSON ANTHONY J
权利人:PROCTER & GAMBLE
摘要:The synthesis of phenol sulfonate esters of alkanoyl amino acids is conducted in the presence of aqueous base to provide bleach activator compounds. Thus, the acid chloride of N-nonanoyl-6-aminocaproic acid is reacted with the sodium salt of p-phenol sulfonate in the presence of water at a pH in the range of about 9 to about 12 to yield the corresponding phenol sulfonate ester. The synthesis of the phenol sulfonate ester of the monononyl amide of adipic acid is also illustrated.

专利号:US-2017327504-A1
优先权日:2014-10-30
标 题:Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
发明人：ROSE CHRISTOPHER; SILBERGER HERBERT; SCHREINER ERWIN; FELZMANN WOLFGANG; MARAS NENAD
权利人:SANDOZ AG
摘要:The present invention refers to the synthesis and intermediates of substituted bicyclic compounds by using a central 1H-pyrazolo[3,4-d]pyrimidine of formula (I), which is assembled starting from 4,6-dichloropyrimidine carboxylic acid. The invention in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one(ibrutinib) and its synthesis intermediates.

专利号:US-10661239-B2
优先权日:2016-04-29
标 题 :Catalytic reactor configuration, preparation and method of direct synthesis of ethylene through oxygen-free catalysis of methane
发明人：BAO XINHE; GUO XIAOGUANG; FANG GUANGZONG; PAN XIULIAN; MENG JINGHENG; YU QINQIN; TAN DALI
权利人:DALIAN INST CHEM & PHYSICS CAS
摘要:A reactor configuration comprises an inlet section I, a preheating section II, a transition section III, a reaction section IV and an outlet section V; except for the preheating section II and the reaction section IV, the existence of the inlet section I, the transition section III and the outlet section V depends on reaction conditions; and the process realizes no coke deposition synthesis of methane and high selectivity synthesis of ethylene. The methane conversion rate is 20-90%; ethylene selectivity is 65-95%; propylene and butylene selectivity is 5-25%; aromatic hydrocarbon selectivity is 0-30%; and coke deposition is zero.

专利号:WO-2022269384-A1
优先权日:2021-06-24
标 题 :A process for the direct synthesis of fedratinib intermediate
发明人：DESAI ASIM HEMANTBHAI; PATIL SANJAY NIMBAJI; RADADIYA VAIBHAV GOVINDBHAI; DESAI JIGNASU THAKORBHAI; DUBEY RAJEEV RAMCHANDRA; CHOUBEY Ajit Kumar
权利人:AMI ORGANICS LTD
摘要:The present disclosure relates to a process for the direct synthesis of Fedratinib intermediate. Particularly, the present disclosure relates to a process for the direct synthesis of 3-amino-N- (tert-butyl)benzene sulfonamide. The process of the present disclosure has various advantages such as convenient operation conditions, time-saving process, easy purification, low operation costs, good yield and efficiency hence the process is industrially feasible. The use of non-toxic, inexpensive and easily available reagents, in the process of the present disclosure, makes the process cost-efficient economic and environmental friendly.