CAS: 129318-43-0; Alendronate Monosodium

专利信息

专利号:US-2007155693-A1
优先权日:2004-01-19
标 题 :Inhibitor of cancer bone metastasis
发明人：YAGITA AKIKUNI
权利人:ORIENT CANCER THERAPY CO LTD
摘要:The subject of the present invention is to provide means to fully achieve the inhibition of cancer bone metastasis, which was accomplished through the repeated selection of agents with aiming at obtaining more beneficial effects on the inhibition of cancer bone metastasis. The invention is achieved by combining an inhibition substance of the activation of osteoclast caused by the degradation of a signaling molecule, TRAF6, in the activation of osteoclast, a suppressive substance of the differentiation from osteoclast precursor cells to mature osteoclasts, and/or a bone resorption inhibitor and/or a Cox2 synthesis inhibitor. This combination was found to have an extremely high utility for the inhibition of cancer bone metastasis. Further, the invention is achieved by the inhibitor of cancer bone metastasis, wherein an IL-12 production inducer as an inhibition substance of the activation of osteoclast caused by the degradation of a signaling molecule, TRAF6, in the activation of osteoclast, a tyrosine kinase inhibitor as a suppressive substance of the differentiation from osteoclast precursor cells to mature osteoclasts, and/or a bisphosphonate as a bone resorption inhibitor and/or a Cox2 synthesis inhibitor for inhibiting the stimulation of RANKL/RANK receptor are combined.

专利号:EP-1399406-B1
优先权日:2001-01-04
标题:Novel estrogen receptor ligands and methods i
发明人：KOEHLER KONRAD; HENSSEN CECILIA; NILSSON MARITA; GILLNER MIKAEL; LIU YE; SANIN ANDREI; WILKENING ROBERT R; RATCLIFFE RONALD W; WENSBO DAVID
权利人:KAROBIO AB; MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant inventive are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynecomastia, autoimmune disease, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer of the lung, colon, breast, uterus, and prrostate.

专利号:WO-9836064-A1
优先权日:1997-02-14
标 题 :Phosphonate binding proteins
发明人：COOK JONATHAN SHAUN; EBETINO FRANK HALLOCK; IBBOTSON KENNETH JOHN; JI XIAOHUI; ROGERS MICHAEL JOHN; WATTS DONALD JEREMY; RUSSELL ROGER GRAHAM GOODWIN R; XIONG XIAO JUAN
权利人:PROCTER & GAMBLE; UNIV SHEFFIELD MED SCHOOL; COOK JONATHAN SHAUN; EBETINO FRANK HALLOCK; IBBOTSON KENNETH JOHN; JI XIAOHUI; ROGERS MICHAEL JOHN; WATTS DONALD JEREMY; RUSSELL ROGER GRAHAM GOODWIN R; XIONG XIAO JUAN
摘要:The present invention relates to proteins capable of binding bisphosphonate or bisphosphonate analogues, to methods for producing and identifying these proteins, to their corresponding genes and to various uses of the proteins, for example, in therapy and in the screening, isolation, synthesis, design and evaluation of bisphosphonate-based drugs.

专利号:CN-1071605-A
优先权日:1991-10-24
标题:From reaction products of oxo synthesis, reclaim the method for rhodium