CAS: 179051-78-6; 4-Chloropyrimidine Hydrochloride

该化合物是一种有机化合物,其特点是其火水环结构,即六人组成的芳香环,含有位于1号位置和3号位置的两个氮原子;在4号位置的铁水环中存在氯原子,有助于其反应和各种化学反应的潜在应用;作为盐盐,它一般是白色到白色的晶状固体,在水和极有机溶剂中溶解;该化合物经常用于制药合成,并用作生产农用化学品和其他精化剂的中间体;其特性包括标准条件下的中度稳定性,但可能对湿度和光度敏感;在处理该化合物时,应采取安全防范措施,因为如果吸入或浸入,可能会对健康造成危害;

英文名称4-Chloropyrimidine Hydrochloride
中文名称4-氯嘧啶盐酸盐
IUPAC名称4-chloropyrimidine hydrochloride
其它别名4-Chloropyrimidine Hydrochloride; 4-Chloro-Pyrimidine Hydrochloride; 4-Chloropyrimidine; Hydrochloride; 4-Chloropyrimidine Hcl; Pyrimidine, 4-Chloro-, Hydrochloride (1:1); Pyrimidine, 4-Chloro-, Monohydrochloride; 4-Chloropyrimidinehydrochloride; 4-Ch
CAS编号179051-78-6
MFCD编号:MFCD11870807
EINECS号:814-000-0
分子式:C4H4Cl2N2
分子量:151.0
产品CID: 921362
产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物

相似结构搜索
InChIKey: HBZJVDNETONGIS-UHFFFAOYSA-N
InChI=1S/C4H3ClN2.ClH/c5-4-1-2-6-3-7-4;/h1-3H;1H…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数0.0

相似化合物

1193-21-1 3934-20-1 3764-01-0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
皮肤致敏类别1
严重眼刺激类别2A
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H317 |可能引起皮肤过敏反应.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi
安全声明26-36/37/39
危险类别码36/37/38

欧盟法规

C&L通报

合成工艺路线路线简述

专利信息

专利号:US-12247037-B2
优先权日:2018-12-12
标题:1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
发明人：BRANDT GARY
权利人:NEUMORA THERAPEUTICS INC
摘要:The present invention relates to 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds of Formula (I): wherein A, B, G, R1, R1b, RiC, R2 and X are as defined herein. The present compounds are vasopressin receptor antagonists (in particular of the Via receptor) for the treatment of neuro-psychological disorders, such as e.g. autism, anxiety, stress-related disorders, depression, schizophrenia or bipolar disorder. The present description discloses the synthesis of exemplary compounds, as well as pharmacological data thereof (e.g. pages 71 to 246; examples 1 to 49; tables 1 to 5). An exemplary compound is e.g. 8-chloro-1-(2-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (example 1, compound no. 1).

专利号:US-10112955-B2
优先权日:2015-10-29
标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
发明人：SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript â€œnâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:US-11858943-B2
优先权日:2017-06-05
标题:Vasopressin receptor antagonists and products and methods related thereto
发明人：JONES ROBERT M; URBANO MARIANGELA; BRANDT GARY; HARDICK DAVID; KNIGHT CHRIS; TIERNEY JASON
权利人:NEUMORA THERAPEUTICS INC
摘要:Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:wherein A, B, G, R1, R1b, R1c, R2 and X are as defined herein.