8-溴-2-甲基喹啉置于copper(I) Oxide,Ammonium Hydroxide,N1-(2-呋喃甲基)-N2-(2-甲基-1-萘基)草酰胺,Potassium Hydroxide体系中,用 乙醇 用作溶剂,化学反应 24.0H,以64%的收率获得8-氨基喹哪啶 参考文献:Discovery Of N-(Naphthalen-1-yl)-N'-Alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination With High Turnovers 标题:Discovery Of N-(Naphthalen-1-yl)-N'-Alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination With High Turnovers 摘要:A Class Of N-(Naphthalen-1-yl)-N'-Alkyl Oxalamides Have Been Proven To Be Powerful Ligands,Making A Coupling Reaction Of (Hetero)Aryl Iodides With Primary Amines Proceed At 50 Degrees C With Only 0.01 Mol % Of Cu2O And Ligand As Well As A Coupling Reaction Of (Hetero)Aryl Bromides With Primary Amines And Ammonia At 80 Degrees C With Only 0.1 Mol % Of Cu2O And Ligand. A Wide Range Of Coupling Partners Work Well Under These Conditions Thereby Providing An Easy To Operate Method For Preparing (Hetero)Atyl Amines. Doi:10.1021/acs.Orglett.7B00901
专利号:US-5468862-A 优先权日:1994-04-25 标题:Synthesis of Solvent Yellow 33 (D & C Yellow 11) with excess phthalic anhydride acid as a solvent 发明人:SUJEETH PUTHALATH K 权利人:WARNER JENKINSON COMPANY 摘要:A process for the manufacture of a quinophthalone, in particular Solvent Yellow 33 (D & C Yellow 11) is described. The quinophthalone, in particular Solvent Yellow 33, is made by a process in which quinaldine is condensed with a molar excess of either phthalic acid or phthalic anhydride, the acid or anhydride being employed not only as a reactant, but also as a solvent for the reaction. This process can also employ phthalic acid (or recycled phthalic acid) and phthalic anhydride together, one as the solvent and the other as the reactant.
专利号:RU-2748114-C1 优先权日:2020-09-11 标 题 :Method of producing a {2,4-di-tert-butyl-6-[(tert-butylimino)methyl]phenolate} pre-catalyst for vanadium(v) oxodichloride for the synthesis of epdm/epm ethylene-propylene rubbers
专利号:CN-111732493-A 优先权日:2017-01-16 标题 :A kind of synthesis technique of aromatic amine compound
专利号:US-11319328-B2 优先权日:2017-08-16 标题 :4β-amino substituted podophyllotoxin derivative and preparation method therefor and use thereof 发明人:TANG YAJIE; ZHAO WEI 权利人:TANG YAJIE 摘要:Disclosed are a 4β-amino substituted podophyllotoxin derivative and a synthesis method therefor and the use thereof. The present invention respectively introduces the aromatic heterocyclic compounds anthraquinone, quinazoline, quinoline, indole, indazole, pyrimidine as substituent groups to position-4 of the C ring in the podophyllotoxin or 4′-demethylepipodophyllotoxin to obtain the podophyllotoxin derivatives as shown in formula (V). Experiments involving in vitro tumour cell activity inhibition show that the antitumour activity of most of the compounds as shown in formula (V) of the present invention is significantly improved compared to that of the patented medicine of podophyllotoxin-“etoposideâ€?.
专利号:CN-117447398-A 优先权日:2023-10-13 标题 :Synthesis method of cyclopentyl-substituted fatty amide
专利号:CN-111732493-B 优先权日:2017-01-16 标题:A kind of synthesis technique of aromatic amine compound