CAS: 211915-84-3; Ethyl 3-(2-(((4-Cyanophenyl)Amino)Methyl)-1-Methyl-N-(Pyridin-2-yl)-1H-Benzo[d]Imidazole-5-Carboxamido)Propanoate

相似化合物

1422435-41-3 429658-95-7 211915-84-3

上下游产品

CAS号42288-26-6 N-(4-氰基苯基)甘氨酸 | CAS号212322-56-0 3-[(3-氨基-4-甲基氨基... | CAS号41263-74-5 4-甲氨基-3-硝基苯甲酸 | CAS号82357-48-0 3-硝基-4-甲胺基-苯甲酰氯 | CAS号429659-01-8 3-(4-(甲基氨基)-3-硝... | CAS号873-74-5 对氨基苯腈 | CAS号96-99-1 4-氯-3-硝基苯甲酸 | CAS号872728-81-9 甲磺酸达比加群酯 | CAS号211915-06-9 达比加群酯

4-氯-3-硝基苯甲酸置于氯化亚砜,Palladium On Activated Charcoal,N,N-二甲基甲酰胺,N,N'-羰基二咪唑体系中,用 乙酸乙酯,甲苯 用作溶剂,化学反应 20.4H,反应生成3-[[[2-[[(4-氰基苯基)氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]吡啶-2-基氨基]丙酸乙酯
参考文献:Process For The Preparation Of Dabigatran Etexilate Mesylate And Polymorphs Of Intermediates Thereof
标题:Process For The Preparation Of Dabigatran Etexilate Mesylate And Polymorphs Of Intermediates Thereof
摘要:本发明提供了formula 2A的中间体的晶型,本发明还提供了达比加群酯甲磺酸盐的制备方法;其中间体的多形态;尤其是制备中间体晶型的方法.本发明还涉及使用晶体中间体制备达比加群酯甲磺酸盐.

专利信息

专利号:US-9533971-B2
优先权日:2012-10-29
标 题 :Process for the synthesis of dabigatran and its intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD; BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.

专利号:US-10077251-B2
优先权日:2012-10-29
标题:Process for the synthesis of Dabigatran Etexilate and its intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.

专利号:US-9365544-B2
优先权日:2012-07-16
标题 :Process for the preparation of intermediates for the synthesis of Dabigatran Etexilate, and crystalline forms of said intermediates
发明人：HERNÀNDEZ GALLEGO SANTOS; MARQUILLAS OLONDRIZ FRANCISCO; POMARES MARCO MARTA
权利人:INTERQUIM SA
摘要:The present invention relates to new processes for the preparation of synthesis intermediate products useful in the preparation of Dabigatran Etexilate on an industrial scale. The invention also relates to new crystalline forms of intermediate products thus obtained.

专利号:US-9273030-B2
优先权日:2012-04-02
标题 :Process for the preparation of benzimidazole derivatives and salts thereof
发明人：THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; RAGHURAM SURAPARAJU
权利人:MSN LAB PRIVATE LTD
摘要:Provided are novel salts of benzimidazole derivatives, preferably salts of benzimidazole derivatives which are useful intermediates in the synthesis of pure 1-methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide and its salts.

专利号:US-9688657-B2
优先权日:2013-03-25
标题:Synthesis of dabigatran
发明人：PATKAR LAXMIKANT NARHARI; MONDKAR HARISH KASHINATH; AROTE NITIN DNYANESHWAR; PATIL SACHIN SHIVAJI; JADHAV TANAJI SHAMRAO; HAGAVANE NITIN NIVRUTTI; BHOPALKAR RAJESH GANPAT
权利人:USV PRIVATE LTD
摘要:The present invention relates to a process for preparation of Dabigatran etexilate or pharmaceutically acceptable salt thereof. The present invention relates to novel compounds, in particular Ethyl-3-{[(2-formyl-1-methyl-1H-benzimidazole-5-yl)carbonyl]-(2-pyridinyl) amino}propanoate and Ethyl-3-{[(2-dichloromethyl-1-methyl-1H-benzimidazole-5-yl)carbonyl]-(2-pyridinyl)amino}propanoate and process for preparation thereof. The present invention further relates to the use of these novel compounds in the preparation of Dabigatran etexilate or pharmaceutically acceptable salt thereof.

专利号:US-2015203470-A1
优先权日:2012-07-16
标 题 :Process for the preparation of intermediates for the synthesis of dabigatran etexilate, and crystalline forms of said intermediates