CAS: 223673-34-5; (1R)-2-[2-(4-Nitrophenyl)Ethylamino]-1-Phenylethanol

上下游产品

(R)-Styrene oxide 2-(p-nitrophenyl)ethylamine (2R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylethanamide α-bromoacetophenone (R)-2-[[2′-(4-nitrophenyl)ethyl]amino]-1-phenylethanol hydr°Chloride

D-扁桃酸置于sodium Tetrahydroborate,三氟化硼乙醚,1-羟基苯并三唑,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,三乙胺体系中,用 四氢呋喃,N,N-二甲基甲酰胺 用作溶剂,化学反应 26.0H,反应生成(Alphar)-Alpha-[[[2-(4-硝基苯基)乙基]氨基]甲基]苯甲醇
参考文献:酰基取代的吡咯烷酰胺衍生物及其用途
标题:酰基取代的吡咯烷酰胺衍生物及其用途
摘要:本发明公开了酰基取代的吡咯烷酰胺衍生物及其用途,具体地,本发明涉及一类新颖的酰基取代的吡咯烷酰胺衍生物以及包含该类化合物的药物组合物,可用于激活β3‑肾上腺素能受体.本发明还涉及制备这类化合物和药物组合物的方法,以及它们在制备治疗由β3‑肾上腺素能受体激活介导的疾病或病症,特别是膀胱过度活动症的药物中的用途.

专利信息

专利号:US-9815771-B2
优先权日:2014-08-06
标题 :Method for the synthesis of mirabegron and its derivatives
发明人：MARQUILLAS OLONDRIZ FRANCISCO; RIEGO ARBOLEYA ESTELA
权利人:INTERQUIM SA
摘要:The present invention refers to a method for the synthesis of a compound of formula (I), solvates, stereoisomers or salts thereof, a key intermediate in the synthesis of Mirabegron by reduction of an amide in the presence of an amine-boranecomplex, wherein the amine is an aniline.

专利号:EP-3177589-A1
优先权日:2014-08-06
标题 :Method for the synthesis of mirabegron and its derivatives

专利号:US-7982049-B2
优先权日:2001-10-30
标 题:α-form or β-form crystal of acetanilide derivative
发明人：KAWAZOE SOUICHIROU; SAKAMOTO KENICHIROU; AWAMURA YUJI; MARUYAMA TATSUYA; SUZUKI TAKAYUKI; ONDA KENICHI; TAKASU TOSHIYUKI
权利人:ASTELLAS PHARMA INC
摘要:To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with α-form crystal and β-form crystal of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide. The α-form crystal does not exhibit hygroscopicity and has stability such that it can be used as a medicine, and is useful for mass synthesis in the industrial production. The β-form crystal does not relatively exhibit hygroscopicity and is also useful as a production intermediate of the α-form crystal.

专利号:US-2017226045-A1
优先权日:2014-08-06
标 题:Method for the synthesis of mirabegron and its derivatives

专利号:EP-3177589-B1
优先权日:2014-08-06
标题:Method for the synthesis of mirabegron and its derivatives

专利号:WO-2016020440-A1
优先权日:2014-08-06
标题 :Method for the synthesis of mirabegron and its derivatives