CAS: 229027-89-8; 2-Bromo-4-Fluorobenzyl Alcohol

上下游产品

2-bromo-4-fluorobenzyl bromide 2-bromo-4-fluorobenzoic acid 2-bromo-4-fluorotoluene 2-bromo-4-fluorobenzaldehyde {4-Fluoro-2-[2-(triisopropylsilyl)ethyn-1-yl]phenyl}methanol 6-fluoroisobenzofuran-1(3H)-one 2-bromo-4-fluoro-1-(methoxymethoxymethyl)benzene 1-benzyl-2-ethynyl-4-fluorobenzene

2-溴-4-氟溴苄置于水,Calcium Carbonate体系中,用 1,4-二氧六环 用作溶剂,化学反应 6.0H,以82%的收率获得2-溴-4-氟苄醇
参考文献:Coupling Reactions Of Ortho-Substituted Halobenzenes With Alkynes. The Synthesis Of Phenylacetylenes And Symmetrical Or Unsymmetrical 1,2-Diphenylacetylenes
标题:Coupling Reactions Of Ortho-Substituted Halobenzenes With Alkynes. The Synthesis Of Phenylacetylenes And Symmetrical Or Unsymmetrical 1,2-Diphenylacetylenes
摘要:对含有甲基,羟甲基,乙酰氧甲基,甲氧羰基或甲氧和4,4-二甲基-4,5-二氢-1,3-噁唑-2-基基团的卤代苯在邻位与气态或金属化的乙炔,(三烷基硅基)乙炔和芳基乙炔的pd-或pd/cu催化偶联反应已被系统研究.各种官能化的芳基或二芳基乙炔已被合成,产率非常好至优异.在苯环上附加额外的氟,硝基或甲氧基不会干扰偶联反应,但甲氧羰基的存在需要仔细优化反应条件以获得中等产率.
Doi:10.1135/cccc19990649

专利信息

专利号:US-7968752-B2
优先权日:2003-06-16
标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.