CAS: 37736-82-6; (S)-2-((Tert-Butoxycarbonyl)Amino)-3-Cyclohexylpropanoic Acid

相似化合物

349560-47-0 144186-13-0 127095-92-5

上下游产品

CAS号13734-34-4 B°C-L-苯丙氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号25528-71-6 β环己基丙氨酸盐酸盐 | CAS号4530-18-1 N-甲基-N-叔丁氧羰基-D-苯丙氨酸 | CAS号27527-05-5 (S)-2-氨基-3-环己基羧酸 | CAS号63-91-2 L-苯丙氨酸 | CAS号2018-61-3 N-乙酰-L-苯丙氨酸 | CAS号100400-96-2 (S)-2-acetylami... | CAS号107202-62-0 [(1S)-(1-(S)-N-... | CAS号103322-56-1 (S)-(-)-2-(B°C-... | CAS号98105-41-0 (S)-2-((叔丁氧基羰基)...

Boc-L-苯丙氨酸置于platinum(Iv) Oxide 氢气体系中,用 乙醇 作为反应溶剂,以98%的收率获得产物丁氧羰基--环乙基-丙氨酸-羟基盐酸盐
参考文献:(2S,4S,5S)-5-氨基-6-环己基-4-羟基-2-异丙基己酸正丁基酰胺的羟乙烯二肽异戊烯的合成
标题:(2S,4S,5S)-5-氨基-6-环己基-4-羟基-2-异丙基己酸正丁基酰胺的羟乙烯二肽异戊烯的合成
摘要:描述了由boc-L-苯丙氨酸立体选择性地合成(2S,4S,5S)-5-氨基-6-环己基-4-羟基-2-异丙基己酸正丁基酰胺的羟基亚乙基二肽等排体.
DOI:10.1016/s0040-4039(00)91634-4

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-5378690-A
优先权日:1986-12-19
标题 :New renin-inhibitory oligopeptides, their preparation and their use
发明人：MORISAWA YASUHIRO; KATAOKA MITSURU; YABE YUICHIRO; IIJIMA YASUTERU; TAKAHAGI HIDEKUNI; KOIKE HIROYUKI; KOKUBU TATSUO; HIWADA KUNIO
权利人:SANKYO CO
摘要:Oligopeptides of formula (I): (I) where R1-R5 are various organic groups, and A represents a group of formula -NH- or -(CH2)n-, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.