O-Pentafluoropropionyl-2-Mercaptoethanol置于三乙胺体系中,用 二乙二醇二甲醚 作为反应溶剂,以70%的收率获得产物环硫乙烷 参考文献:Formation Of C-s Bond By The Elimination Of Perfluorocarboxylic Acid 标题:Formation Of C-s Bond By The Elimination Of Perfluorocarboxylic Acid 摘要:Thiirane可以通过与三乙胺的分子内消除反应,方便地从2-巯基乙基三氟乙酸酯或五氟丙酸酯反应生成.烷基苄基硫化物也可以通过与苄基三氟乙酸酯或五氟丙酸酯和烷基硫醇的分子间消除反应合成. DOI:10.1246/bcsj.53.2097
专利号:US-12421534-B2 优先权日:2021-11-10 标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs 发明人:ALMHJELL PATRICK J; ARNOLD FRANCES H 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.
专利号:US-11858953-B2 优先权日:2018-04-04 标 题:Compositions and methods for synthesis of phosphorylated molecules 发明人:CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT 权利人:UNIV CALIFORNIA 摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.
专利号:US-7429658-B2 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines 发明人:HOWARD PHILIP; MASTERSON LUKE 权利人:SPIROGEN LTD 摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):
专利号:US-10040752-B2 优先权日:2015-08-24 标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof 发明人:MKRTCHYAN GNEL; YAO QINGWEI 权利人:CODY LABORATORIES INC 摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.
专利号:US-10995076-B2 优先权日:2017-05-24 标 题:Halogenated benzoxazine for use in the synthesis of polybenzoxazine 发明人:FEDURCO MILAN; RIBEZZO MARCO 权利人:MICHELIN & CIE 摘要:A halogenated benzoxazine compound, which can be used in particular as monomer in the synthesis of polybenzoxazine, corresponds to the formula (the symbol Hal representing at least one halogen): n nin which: each benzene nucleus bears at least one halogen; R 1 and R 2 , which are identical or different, represent hydrogen or an alkyl comprising from 1 to 8 carbon atoms; “x 1 â€? and “x 2 â€?, which are identical or different, are integers equal to or greater than 1; “x 3 â€? is an integer equal to or greater than 1; and X is a heteroatom chosen from O and S.
专利号:US-7557099-B2 优先权日:2004-03-01 标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines 发明人:HOWARD PHILIP WILSON; KANG GYOUNG-DONG 权利人:SPIROGEN LTD 摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.
参考文献:10.1107/s1600536811010245 摘要:Abe D, Sasanuma Y, Sato H. Ethane-1,2-diyl bis-(benzene-dithio-ate). Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o961. 参考文献:10.1186/2046-0481-63-8-498 摘要:Gutierrez J, Eisenberg RL, Koval NJ, Armstrong ER, Tharappel J, Hughes CG, Tobin T. Pemoline and tetramisole 'positives' in English racehorses following levamisole administration. Irish Veterinary Journal. 2010 Aug 01;63(8):498. doi: 10.1186/2046-0481-63-8-498.