专利号:US-10882819-B2 优先权日:2018-09-26 标 题 :Synthesis of novel intermediate(s) for preparing rivastigmine 发明人:YADAV JHILLU SINGH; EPPA GYANCHANDER; VACHHARAJANI PRANAV RAMESHBHAI; VEKARIYA NUTAN BHARATBHAI; BHAVSAR CHETAN UMESHBHAI; MODI RAJIV INDRAVADAN; KHAMAR BAKULESH MAFATLAL 权利人:CADILA PHARMACEUTICALS LTD; CADILA CORP CAMPUS 摘要:The present invention relates to novel intermediate(s), which are useful for the preparation of Rivastigmine compound of formula (I) and its pharmaceutically acceptable salts. The present invention further relates to the processes for the preparation of such novel intermediate(s) and preparation of Rivastigmine using such novel intermediate(s).
专利号:US-7476757-B2 优先权日:2005-02-22 标 题:Process for the synthesis of enantiomeric indanylamine derivatives 发明人:BOULTON LEE TERENCE; LENNON IAN CAMPBELL; BAHAR ELIEZER 权利人:TEVA PHARMA 摘要:A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or pressure hydrogenation in the presenc of an optically active catalyst to reduce 1-indanones. The chiral product, either (S)- or (R)-indanols undergo nucleophilic substitution to produce the named product. In an additional aspect, the invention relates to novel intermediates and compounds, namely, substituted indanones, substituted (S)-indanols and substituted (R)-indanols.
专利号:US-2006199974-A1 优先权日:2005-02-22 标 题:Process for the synthesis of enantiomeric indanylamine derivatives
专利号:US-2020095195-A1 优先权日:2018-09-26 标 题:Synthesis of novel intermediate(s) for preparing rivastigmine
专利号:US-2008200720-A1 优先权日:2005-02-22 标题:Process for the synthesis of enantiomeric indanylamine derivatives
专利号:US-7375249-B2 优先权日:2005-02-22 标 题:Process for the synthesis of enantiomeric indanylamine derivatives
参考标题:Synthesis Of Novel Intermediate(S) For Preparing Rivastigmine 摘要:The Present Invention Relates To Novel Intermediate(S), Which Are Useful For The Preparation Of Rivastigmine Compound Of Formula (I) And Its Pharmaceutically Acceptable Salts. The Present Invention Further Relates To The Processes For The Preparation Of Such Novel Intermediate(S) And Preparation Of Rivastigmine Using Such Novel Intermediate(S).