CAS: 627-00-9; 4-Chlorobutanoic Acid

该化合物是一种有机化合物,其特点是其碳酸功能组和与四碳丁酸链的第四颗碳相连的氯原子,其分子式为C4H7ClO2,其分子重量约为110.55克/摩尔,该化合物一般是无色的,可视温度和纯度而定,为黄色液体或固体;在水和有机溶剂中溶解,使其具有多种用途. 4-氯丁酸因其活性而闻名,特别是由于存在氯原子,可被其他核细胞替代反应,可被其他核细胞替代反应,用于有机合成,特别是用于生产药品,农用化学品,并作为其他化学化合物合成的中间体.在处理该物质时,应当采取安全防范措施,因为它可能会对皮肤,眼睛和呼吸系统产生刺激.

结构式图片

相似化合物

3153-37-5 628-20-6 928-51-8

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-pyrrolidinon 4-butanolide 4-chloro-butyric acid ethyl ester N-nitroso-dihydro-2(3H)-pyrrolidinone methyl 4-chlorobutyrate S)-4-chloro-butyric acid sec-butyl ester(S)-4-chloro-butyric acid sec-butyl ester 2-pyrrolidinon 4-hydroxybutanoic acid

合成工艺路线路线简述

    4-氯丁醇 反应生成 4-氯丙酸
    参考文献:Mathew,K. K.; Raman,P. S.; Antharjanam,T. G. Bhargavi,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1981,Vol. 20,# 4,P. 340-342
    标题:Mathew,K. K.; Raman,P. S.; Antharjanam,T. G. Bhargavi,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1981,Vol. 20,# 4,P. 340-342

    海关参考信息

    专利信息


    专利号:WO-03031376-A1
    优先权日:2001-10-12
    标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one
    发明人:MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
    权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
    摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.

    专利号:US-6159673-A
    优先权日:1996-07-17
    标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound
    发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI
    权利人:FUJI PHOTO FILM CO LTD
    摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.

    专利号:WO-2017175233-A1
    优先权日:2016-04-04
    标 题:Process for large scale liquid phase synthesis of carbetocin and its novel intermediates
    发明人:Mohammed Khalid Anwer; Mohammed Mohosin Layek
    权利人:DAVULURI RAMAMOHAN RAO
    摘要:A process for large scale liquid phase synthesis of Carbetocin is disclosed. Novel intermediates of formula (A), formula (B), and processes for their preparation are also disclosed.

    专利号:EP-1473330-B1
    优先权日:1996-07-17
    标题:Process for the synthesis of oxonol compound
    发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI
    权利人:FUJI PHOTO FILM CO LTD
    摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.

    专利号:US-5714127-A
    优先权日:1992-10-08
    标题 :System for multiple simultaneous synthesis
    发明人:DEWITT SHEILA H H; KIELY JOHN S; PAVIA MICHAEL R; SCHROEDER MEL C; STANKOVIC CHARLES J
    权利人:WARNER LAMBERT CO
    摘要:A system for the multiple, simultaneous synthesis of compounds preferably uses a reaction apparatus comprising a reservoir rack having a plurality of reaction wells, a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends, a holder block, having a plurality of apertures, and a manifold, which has ports to allow introduction/maintenance of a controlled environment. The manifold top wall has a plurality of apertures in axial alignment with the reaction tubes and a gasket which allows penetration by a needle in order to dispense and aspirate materials from the reaction tubes. Sealing members, such as gaskets, are placed between the holder block, manifold and reservoir rack and the components are releasably fastened together. A robotic sample processor is used to automate the synthesis process using the reaction apparatus.

    专利号:US-5702672-A
    优先权日:1992-10-08
    标 题 :Apparatus and method for multiple simultaneous synthesis
    发明人:DEWITT SHEILA H H; KELL MICHAEL; PAVIA MICHAEL R; KIELY JOHN S; SCHROEDER MEL C; STANKOVIC CHARLES J; WARE STEVEN
    权利人:WARNER LAMBERT CO
    摘要:An apparatus for multiple, simultaneous synthesis of compounds which consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.
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    主要参考文献

    参考标题:Synthesis Of Piperidine Derivatives By Rhodium- Catalyzed Tandem Reaction OfN-Sulfonyl-1,2,3-Triazole And Vinyl Ether
    作者:Sisi Yu,Yuehui An,Wenlin Wang,Ze-Feng Xu,Chuan-Ying Li |发布日期:2018.6.5
    摘要:A Chemoselective Tandem Reaction Of 4‐acyloxymethylene‐1‐sulfonyl‐1,2,3‐triazole And Vinyl Ether Was Reported, Producing Polysubstituted Piperidine Derivatives In Up To 96% Yield. The Key Intermediate N‐sulfonyl 1‐azadiene Generated By Migration Of The Oac Group To The α‐imino Rhodium Carbene Was Isolated And A Plausible Mechanism Was Proposed. Several Related Ring Systems Were Constructed From The

    合成参考文献


    摘要:Takaya, J.; Iwasawa, N., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 270.
    摘要:Lei, A.; Tang, S., Science of Synthesis: Knowledge Updates, (2023) 1, 116.
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