4-氯丁醇 反应生成 4-氯丙酸 参考文献:Mathew,K. K.; Raman,P. S.; Antharjanam,T. G. Bhargavi,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1981,Vol. 20,# 4,P. 340-342 标题:Mathew,K. K.; Raman,P. S.; Antharjanam,T. G. Bhargavi,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1981,Vol. 20,# 4,P. 340-342
专利号:WO-03031376-A1 优先权日:2001-10-12 标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one 发明人:MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.
专利号:US-6159673-A 优先权日:1996-07-17 标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound 发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI 权利人:FUJI PHOTO FILM CO LTD 摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.
专利号:WO-2017175233-A1 优先权日:2016-04-04 标 题:Process for large scale liquid phase synthesis of carbetocin and its novel intermediates 发明人:Mohammed Khalid Anwer; Mohammed Mohosin Layek 权利人:DAVULURI RAMAMOHAN RAO 摘要:A process for large scale liquid phase synthesis of Carbetocin is disclosed. Novel intermediates of formula (A), formula (B), and processes for their preparation are also disclosed.
专利号:EP-1473330-B1 优先权日:1996-07-17 标题:Process for the synthesis of oxonol compound 发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI 权利人:FUJI PHOTO FILM CO LTD 摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.
专利号:US-5714127-A 优先权日:1992-10-08 标题 :System for multiple simultaneous synthesis 发明人:DEWITT SHEILA H H; KIELY JOHN S; PAVIA MICHAEL R; SCHROEDER MEL C; STANKOVIC CHARLES J 权利人:WARNER LAMBERT CO 摘要:A system for the multiple, simultaneous synthesis of compounds preferably uses a reaction apparatus comprising a reservoir rack having a plurality of reaction wells, a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends, a holder block, having a plurality of apertures, and a manifold, which has ports to allow introduction/maintenance of a controlled environment. The manifold top wall has a plurality of apertures in axial alignment with the reaction tubes and a gasket which allows penetration by a needle in order to dispense and aspirate materials from the reaction tubes. Sealing members, such as gaskets, are placed between the holder block, manifold and reservoir rack and the components are releasably fastened together. A robotic sample processor is used to automate the synthesis process using the reaction apparatus.
专利号:US-5702672-A 优先权日:1992-10-08 标 题 :Apparatus and method for multiple simultaneous synthesis 发明人:DEWITT SHEILA H H; KELL MICHAEL; PAVIA MICHAEL R; KIELY JOHN S; SCHROEDER MEL C; STANKOVIC CHARLES J; WARE STEVEN 权利人:WARNER LAMBERT CO 摘要:An apparatus for multiple, simultaneous synthesis of compounds which consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.
参考标题:Synthesis Of Piperidine Derivatives By Rhodium- Catalyzed Tandem Reaction OfN-Sulfonyl-1,2,3-Triazole And Vinyl Ether 作者:Sisi Yu,Yuehui An,Wenlin Wang,Ze-Feng Xu,Chuan-Ying Li |发布日期:2018.6.5 摘要:A Chemoselective Tandem Reaction Of 4‐acyloxymethylene‐1‐sulfonyl‐1,2,3‐triazole And Vinyl Ether Was Reported, Producing Polysubstituted Piperidine Derivatives In Up To 96% Yield. The Key Intermediate N‐sulfonyl 1‐azadiene Generated By Migration Of The Oac Group To The α‐imino Rhodium Carbene Was Isolated And A Plausible Mechanism Was Proposed. Several Related Ring Systems Were Constructed From The
合成参考文献
摘要:Takaya, J.; Iwasawa, N., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 270. 摘要:Lei, A.; Tang, S., Science of Synthesis: Knowledge Updates, (2023) 1, 116.