CAS: 108321-42-2; (2R,3S,4R,5R,6S)-5-Amino-6-(((1R,2S,3S,4R,6S)-4,6-Diamino-3-(((2R,3R,4R,5R)-3,5-Dihydroxy-5-Methyl-4-(Methylamino)Tetrahydro-2H-Pyran-2-yl)Oxy)-2-Hydroxycyclohexyl)Oxy)-2-((R)-1-Hydroxyethyl)Tetrahydro-2H-Pyran-3,4-Diol Bis(Sulfate)

Geneticin置于ammonium Hydroxide,硫酸体系中,用 甲醇,氯仿 用作溶剂,化学反应生成G-418 硫酸盐
参考文献:Wo2012/79039
标题:Wo2012/79039

专利信息

专利号:US-2024101632-A1
优先权日:2021-01-27
标 题:Genetically engineered electrically-stimulated effector cells for in situ synthesis of proteins
发明人：BHATNAGAR PARIJAT; NEWMYER SHERRI
权利人:STANFORD RES INST INT
摘要:An example genetically engineered electrically-stimulated (ES) cell comprises an exogenous polynucleotide sequence that includes an electrical-sensor element, an actuator element, and an effector element. The electrical-sensor element encodes a voltage-gated calcium ion channel (CaV), wherein the CaV is configured to transition from a closed state to an open state in response to stimulation. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein, wherein, in response to the transition of the CaV to the open state, the genetically engineered ES effector cell is configured to activate and, to synthesize and secrete the effector protein.

专利号:WO-2022165079-A1
优先权日:2021-01-27
标 题 :Genetically engineered electrically-stimulated effector cells for in situ synthesis of proteins

专利号:US-2025136617-A1
优先权日:2022-02-07
标 题:Small molecules cxcr4 agonists, method of synthesis, and method of use
发明人：LIECHTY KENNETH; MALANY SIOBHAN; PEDDIBHOTLA SATYAMAHESHWAR; ZGHEIB CARLOS
权利人:UNIV COLORADO REGENTS; UNIV FLORIDA
摘要:Small molecule CXC chemokine receptor type 4 (CXCR4) agonists are disclosed, methods of their manufacture, and uses thereof, in particular to improve healing and reduce the risk of injury for wound healing in diabetes.

专利号:EP-4284396-A1
优先权日:2021-01-27
标题 :Genetically engineered electrically-stimulated effector cells for in situ synthesis of proteins

专利号:WO-2023150377-A1
优先权日:2022-02-07
标 题:Small molecule cxcr4 agonists, method of synthesis, and method of use