CAS: 133099-09-9; (S)-2,2-Diphenyl-2-(1-Tosylpyrrolidin-3-yl)Acetonitrile

相似化合物

194602-27-2 24476-55-9 750607-84-2

上下游产品

Diphenylacetonitrile (+)-3-chloro-1-(toluene-4-sulfonyl)-pyrrolidine p-toluenesulfonyl chloride (R)-1-tosylpyrrolidin-3-ol (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetonitrile (S)-darifenacin hydrobromide 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide darifenacin hydr°Chloride

对甲苯磺酰氯置于氢氧化钾,三乙胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 31.0H,反应生成(S)-1-对甲苯磺酰基-3-(1-氰基-1,1-二苯甲基)吡咯烷
参考文献: Novel And Improved Processes For The Preparation Of Intermediates Of Darifenacin,Darifenacin And Its Pharmaceutically Acceptable Salts[fr] Procédés Nouveaux Et Perfectionnés Pour La Préparation D'Intermédiaires De Darifénacine,De La Darifénacine Et De Ses Sels Pharmaceutiquement Acceptables
标题: Novel And Improved Processes For The Preparation Of Intermediates Of Darifenacin,Darifenacin And Its Pharmaceutically Acceptable Salts[fr] Procédés Nouveaux Et Perfectionnés Pour La Préparation D'Intermédiaires De Darifénacine,De La Darifénacine Et De Ses Sels Pharmaceutiquement Acceptables

专利信息

专利号:WO-2009153649-A1
优先权日:2008-06-19
标 题:Process for preparing 3-substituted pyrrolidine compounds
发明人：SOLDEVILLA MADRID NURIA
权利人:MEDICHEM SA; SOLDEVILLA MADRID NURIA
摘要:Disclosed is a process for preparing 3 -substituted pyrrolidine compounds of formula (VII) or salts thereof, wherein R1 is described herein, which are intermediate compounds useful for the synthesis of darifenacin which is indicated for the treatment of overactive bladder with symptoms of urge, urinary incontinence, and the like, and pharmaceutically acceptable salts thereof. Also disclosed is a process for preparing darifenacin and pharmaceutically acceptable salts thereof.