CAS: 14543-43-2; 2-Amino-4-Cyanophenol

相似化合物

1571-72-8 3272-08-0 95-84-1

上下游产品

4-羟基-3-硝基苯甲腈 4-Hydroxy-3-Nitrobenzonitrile 3272-08-0
4-羟基苯甲腈 4-Cyanophenol 767-00-0

4-羟基苯甲腈置于palladium 10% On Activated Carbon,氢气,硝酸,溶剂黄146体系中,用 甲醇 用作溶剂,化学反应 13.0H,反应生成2-氨基-4-氰基苯酚
参考文献:针对黄嘌呤氧化酶中的子口袋:2-[4-烷氧基-3-(1H-四唑-1-基)苯基]-6-氧代-1,6-二氢嘧啶-5-羧酸的设计,合成和生物学评估衍生品.
标题:针对黄嘌呤氧化酶中的子口袋:2-[4-烷氧基-3-(1H-四唑-1-基)苯基]-6-氧代-1,6-二氢嘧啶-5-羧酸的设计,合成和生物学评估衍生品.
摘要:黄嘌呤氧化酶是治疗高尿酸血症,痛风和其他相关疾病的重要靶标.用非布司他对黄嘌呤氧化酶的高分辨率结构进行分析,确定存在由残基leu648,Ans768,Lys771,Leu1014和pro1076形成的亚口袋.在这项研究中,我们设计并合成了一系列2-[4-烷氧基-3-(1H-四唑-1-基)苯基]-6-氧代-1,6-二氢嘧啶-5-羧酸衍生物(8A-8Z)具有靶向黄嘌呤氧化酶活性位点这一亚口袋的四唑基,并且进一步评估了它们在体外对黄嘌呤氧化酶的抑制能力.结果表明,所有测试的化合物(8A-8Z)均表现出明显的黄嘌呤氧化酶抑制能力,Ic50值为0.0288μm至0.629μm.他们之中,化合物8U成为最有效的黄嘌呤氧化酶抑制剂,Ic50值为0.0288μm,与非布索坦相当(ic50 = 0.0236μm).结构-活性关系结果表明,在体外对黄嘌呤氧化酶的抑制能力中,4'-位的疏水基团是必不可少的
Doi:10.1016/j.Ejmech.2019.07.062

专利信息

专利号:US-2003009034-A1
优先权日:2001-03-22
标题 :Transition metal mediated process
发明人：WISHART NEIL; RITTER KURT
摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.

专利号:US-2003109714-A1
优先权日:2001-03-22
标题 :Transition metal mediated process
发明人：WISHART NEIL; RUDOLPH ALENA; RITTER KURT
摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.

专利号:US-9917260-B2
优先权日:2013-08-23
标题 :Compounds with terminal heteroarylcyanovinylene groups and their use in organic solar cells
发明人：SUNDARRAJ SUDHAKAR; EICKHOFF CHRISTIAN; BAHULAYAN SHEEJA; SEND ROBERT; NISHIMAE YUICHI; REICHELT HELMUT; TANABE JUNICHI; ERK PETER
权利人:BASF SE
摘要:The present invention relates to a photoactive material comprising a donor substance and an acceptor substance, wherein the donor substance comprises or consists of one or more compounds of formula (I) described herein, or the acceptor substance comprises or consists of one or more compounds of formula (I) described herein, or the donor substance comprises or consists of a first compound of formula (I) described herein and the acceptor substance comprises a second compound of formula (I) described herein with the proviso that the first and second compound are not the same, as well as to an organic solar cell comprising said photoactive material. The present invention also relates to a photoelectric conversion device comprising or consisting of two or more organic solar cells comprising said photoactive material and to compounds of formula (I) as described herein for use as donor substance or as acceptor substance in a photoactive material, Further, the present invention relates to the use of a compound of formula (III) as described herein in the synthesis of a compound of formula (I)as described herein.