3-氧代-2-苯氧基丁酸乙酯置于氢氧化钾,硫酸体系中,用 甲醇 用作溶剂,化学反应 25.0H,反应生成3-甲基苯并呋喃-2-羧酸 参考文献:Ambient Temperature Method For The Generation And Diels-alder Trapping Of Benzofuran-2,3-Quinodimethane (2,3-Dimethylidene-2,3-Dihydrobenzofuran) 标题:Ambient Temperature Method For The Generation And Diels-alder Trapping Of Benzofuran-2,3-Quinodimethane (2,3-Dimethylidene-2,3-Dihydrobenzofuran) 摘要:The Ito-Saegusa Method Has Been Used To Generate Benzofuran-2,3-Quinodimethane 10 From The Corresponding Silyl Acetate 17B In Solution At-4 Degrees C. The Intermediate Reacts Efficiently With A Range Of Reactive Diels-Alder Dienophiles With Moderate To Good Levels Of Regioselection; The Structure Of The Major Diastereoisomer Has Been Determined By X-Ray Analysis. Doi:10.1039/p19960002827
专利号:US-2021107859-A1 优先权日:2018-04-06 标题 :A process for the synthesis of carbon labeled organic compounds 发明人:AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA 权利人:COMMISSARIAT ENERGIE ATOMIQUE 摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.
专利号:WO-9427985-A1 优先权日:1993-05-28 标题 :Process for the preparation of substituted 3-halomethyl-benzothiophenes, benzofurans and -indoles and intermediates thereof 发明人:PRIDGEN LENDON NORWOOD 权利人:SMITHKLINE BEECHAM CORP; PRIDGEN LENDON NORWOOD 摘要:This invention relates to novel intermediates and processes for preparing useful intermediates of formula (I) which are useful in the synthesis of pharmaceutically active agents.
专利号:EP-3515880-B1 优先权日:2017-03-17 标题:Methods and compositions for synthesis of encoded libraries 发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN 权利人:HITGEN INC
专利号:US-2020149034-A1 优先权日:2017-03-17 标题:Methods and Compositions for Synthesis of Encoded Libraries
专利号:EP-3549927-A1 优先权日:2018-04-06 标 题:A process for the synthesis of carbon labeled organic compounds
专利号:WO-2019193068-A1 优先权日:2018-04-06 标 题:A process for the synthesis of carbon labeled organic compounds
参考标题:Brønsted Acid Catalyzed Dearomatization By Intramolecular Hydroalkoxylation/claisen Rearrangement: Diastereo‐ And Enantioselective Synthesis Of Spirolactams 作者:Peng‐fei Chen,Bo Zhou,Peng Wu,Binju Wang,Long‐wu Ye |发布日期:2021.12.20 摘要:A Brønsted Acid Catalyzed Intramolecular Hydroalkoxylation/claisen Rearrangement Is Disclosed That Involves An Unexpected Dearomatization Of Nonactivated Arenes And Heteroaromatic Compounds And Allows The Practical And Atom-Economic Synthesis Of Various Valuable Spirolactams. Moreover, The Asymmetric Version Of This Tandem Cyclization Is Also Achieved Via Kinetic Resolution By Chiral Phosphoric Acid
合成参考文献
摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 99. 摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 97. 摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 29. 摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 316. 摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 113.