CAS: 3300-51-4; 4-(Trifluoromethyl)Benzylamine

上下游产品

CAS号455-18-5 对三氟甲基苯腈 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号2627-86-3 (S)-(-)-α-甲基苄胺 | CAS号1891-90-3 4-(三氟甲基)苯甲酰胺 | CAS号66046-34-2 N-[[4-(trifluor... | CAS号1146365-23-2 5-((4-(trifluor... | CAS号1146365-12-9 5,5'-(4-(triflu... | CAS号455-18-5 对三氟甲基苯腈 | CAS号1891-90-3 4-(三氟甲基)苯甲酰胺 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号2387-23-7 N,N’-二环己基脲 | CAS号25771-21-5 N,N-二甲基-4-(三氟甲基)苯甲酰胺 | CAS号102422-55-9 4-(三氟甲基L)苄基异氰酸酯 | CAS号34239-04-8 1-苄基-4-三氟甲基苯 | CAS号311769-61-6 5-amino-2-metho... | CAS号134384-31-9 2-(4-Trifluorom...

对三氟甲基苯腈置于氨,氢气体系中,用 水,异丙醇 作为反应溶剂,100.0 °C,2.0 Mpa 条件下,反应 24.0H,以99%的收率获得产物4-(三氟甲基)苄胺
参考文献:高效和通用腈加氢的最先进多相催化剂.
标题:高效和通用腈加氢的最先进多相催化剂.
摘要:制备了由金属氧化物和几丁质衍生的碳组成的钴掺杂杂化材料,对其进行了表征并进行了工业相关腈加氢测试.在700oc下热解后,负载在mgo上的最佳催化剂显示了用碳包裹的co纳米颗粒修饰的氧化镁纳米立方体.这种特殊的结构允许在温和的条件下(例如70°C,20 Bar H 2)将各种苛刻的腈选择性氢化为相应的伯胺.).这种新型催化材料的优势在工业上重要的底物上得到了展示,这些底物包括己二腈,吡咯腈和脂肪酸腈.值得注意的是,在这些转换中,开发的系统优于所有其他经过测试的商业催化剂,例如阮内镍,甚至贵金属基系统.
DOI:10.1002/chem.202001866

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-2024051897-A1
优先权日:2022-07-26
标题:Synthesis of complex 15n-labeled molecules
发明人：DORSHEIMER JULIA; ROVIS TOMISLAV
权利人:UNIV COLUMBIA
摘要:Methods for conversion of a broad range of amines to their 15N isotopic counterparts and the compounds produced thereby.

专利号:US-2025049791-A1
优先权日:2023-08-03
标题:Synthesis of MEK7 Inhibitors and methods of Use Thereof
发明人：SCHEIDT KARL A; KIM DALTON ROBERT; ORR MEGHAN JO
权利人:UNIV NORTHWESTERN
摘要:Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.

专利号:US-2003092064-A1
优先权日:2001-04-05
标题 :System for the synthesis of spatially separated libraries of compounds and methods for the use thereof
发明人：READER JOHN C
权利人:MILLENNIUM PHARM INC
摘要:Featured is an apparatus useful for preparing combinatorial libraries of compounds in a parallel fashion so that the individual compounds of the library are spatially separate and the position of each compound of the library in the apparatus is known. Moreover, the apparatus is useful for the preparation of combinatorial libraries of compounds where the library is constructed from three or more building blocks, e.g., three, four, five, six or seven building blocks, resulting in a three, four, five, six or seven dimensional combinatorial library. Also featured are related methods for the preparation of three, four, five, six or seven dimensional combinatorial libraries of compounds using the apparatus of the present invention.

专利号:WO-2013027225-A1
优先权日:2011-08-19
标 题:Processes for the preparation of 4-{4-[5(s)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl} morpholin-3-one
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:The present invention provides simple, eco-friendly, cost-effective, reproducible, robust and industrial processes for the preparation of intermediate compound 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one (II). The present invention also provides novel intermediates and their use in the synthesis of morpholinone oxazolidine derivatives.

专利号:US-6187923-B1
优先权日:1998-11-09
标题 :Process for the synthesis of quinazolinones
发明人：DENER JEFFREY MARK; LY CUONG QUOC
权利人:AXYS ADVANCED TECHNOLOGIES INC
摘要:The present invention provides a process for synthesizing a compound or a library of compounds of Formula 1A and 1B: