CAS: 56107-02-9; 4-Chloro-3-Nitrobenzophenone

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CAS号96-99-1 4-氯-3-硝基苯甲酸 | CAS号38818-50-7 4-氯-3-硝基苯甲酰氯 | CAS号71-43-2 苯 | CAS号39070-63-8 3,4-二氨基二苯甲酮 | CAS号31431-19-3 4-氨基-3-硝基二苯甲酮 | CAS号66353-69-3 [3-amino-4-(met... | CAS号66353-71-7 4-(Methylamino)... | CAS号82571-94-6 4-methoxy-3-nit... | CAS号91713-63-2 6-苯甲酰基-1,3-二氢-2... | CAS号62261-38-5 3-Amino-4-chlor... | CAS号56106-98-0 [4-(4-methylpip... | CAS号56106-89-9 [4-(dipentylami... | CAS号56106-95-7 [4-(az°Can-1-yl...

4-氯-3-硝基苯甲酸置于三氯化铝,草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 3-硝基-4-氯二苯甲酮
参考文献:Utility Of Complementary Molecular Reactivity And Molecular Recognition (Cmr/r) Technology And Polymer-Supported Reagents In The Solution-Phase Synthesis Of Heterocyclic Carboxamides
标题:Utility Of Complementary Molecular Reactivity And Molecular Recognition (Cmr/r) Technology And Polymer-Supported Reagents In The Solution-Phase Synthesis Of Heterocyclic Carboxamides
摘要:The Use Of Our Recently Reported Chemical Library Purification Strategy In The Development Of A Herbicidal Lead,N-(3-Benzoylphenyl)-3-(1,1-Dimethylethyl)-1-Methyl-1H-Pyrazole-5-Carboxamide (3),Is Described. The Approach Applying Fundamental Properties Of Complementary Molecular Reactivity And Molecular Recognition (Cmr/r) As The Basis For A General Purification Strategy Was Utilized. Polymeric Reagents Were Used In The Synthesis To Generate Reactive Species Involved In Product Formation,And Complementary Molecular Reactivity/molecular Recognition Polymer 8 (Cmr/r Polymer 8) Was Used In The Solution-Phase Syntheses Of Building Blocks,Primary Libraries,And Lead Refinement Libraries. An Extension Of The Cmr/r Methodology Was Applied,Utilizing A Sequestration Enabling Reagent (Ser),Transforming A Reactant Into An Electrophilic Species Sequestrable By Cmr/r Polymer 8. This Library Purification Strategy Enabled Rapid Lead Generation And Lead Refinement To Afford Herbicide 27O. The Cmr/r Solid-Phase Purification Technique Enabled A Simple,General,And Powerful Protocol,Eliminating The Usual Tedious And Time-Consuming Methods Required For Solution-Phase Product Purification. The Result Was The Synthesis Of Hundreds Of Compounds,Prepared In A Relatively Short Time,Leading To A Compound With A 4-Fold Improvement In Herbicidal Activity Over The Initial Lead.
DOI:10.1021/jo970571I

专利信息

专利号:CN-103304468-A
优先权日:2012-03-13
标 题 :A kind of one-pot tandem synthesis method of oxindole