专利号:US-5494918-A 优先权日:1991-03-08 标题 :Multicyclic tertiary amine polyaromatic squalene syntase inhibitors 发明人:NEUENSCHWANDER KENT; AMIN DILIP; SCOTESE ANTHONY C; MORRIS ROBERT L 权利人:RHONE POULENC RORER PHARMA 摘要:This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
专利号:WO-9215579-A1 优先权日:1991-03-08 标 题 :Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors 发明人:NEUENSCHWANDER KENT; AMIN DILIP; SCOTESE ANTHONY C; MORRIS ROBERT L 权利人:RHONE POULENC RORER INT 摘要:This invention relates to polycyclic compounds containing two mono and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
专利号:US-2010010219-A1 优先权日:2006-12-07 标 题 :Method for producing pyrrolidine compound 发明人:HARADA KAZUHITO; ITO TAKASHI 权利人:JAPAN TOBACCO INC 摘要:Provided is a method capable of efficiently producing a compound having a superior HSD1 inhibitory action and a compound useful as a synthetic intermediate therefor, with superior achievability of asymmetric synthesis (i.e., superior selectivity), superior yield, superior safety and superior industrial workability at a low cost. n A method of producing a compound represented by the following formula [8]: n n n n n n n n n n or a salt thereof, or a solvate thereof, from a compound represented by the following formula [2]: n n n n n n n n n n or a reactive derivative thereof, or a salt thereof, or a solvate thereof.
专利号:CN-113789527-B 优先权日:2021-09-10 标 题 :A kind of electrochemical synthesis method of aromatic amine
专利号:CN-116120213-B 优先权日:2021-06-11 标 题:Synthesis method of trans-4-(tert-butyloxycarbonylamino)cyclohexanecarboxylic acid
专利号:CN-113789527-A 优先权日:2021-09-10 标 题 :Electrochemical synthesis method of aromatic amine
摘要:Santana, V. C. S.; Munaretto, L. S.; de Lucca, E. C., Jr., Science of Synthesis Knowledge Updates, (2022) 1, 206. 摘要:Vicens, L.; Palone, A.; Costas, M., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 486.