CAS: 6322-49-2; 4-Chloro-2-Butanone

相似化合物

5891-21-4 10226-30-9 616-27-3

上下游产品

4-chloro-2-butanol 1-Hydroxy-3-butanone methyl vinyl ketone 4-chloro-1,2-butadiene H-phenanthren-2-one8-methoxy-4a-methyl-4,4a,9,10-tetrahydro-3H-phenanthren-2-one 8a-hydroxy-4a-methyl-6-(2-methyl-cyclohexyl)-°Ctahydro-naphthalen-2-one methyl(3-oxobutyl)propanedioic acid diethyl ester 1-Chlor-3-methyl-pentan-3-ol

丁烯酮置于盐酸体系中,化学反应生成 β-氯代丁酮
参考文献:用硫缩醛和相关物质进行实验.第四部分 宝石-双烷硫基丙烯和-丁烯的阴离子重排
标题:用硫缩醛和相关物质进行实验.第四部分 宝石-双烷硫基丙烯和-丁烯的阴离子重排
摘要:如文献中的差异的结果,已经进行了进一步的调查关于某些bisalkylthioalkenes的身份和两种异构体之间的平衡可能存在,R 1个ch:Ch.ch(sr 2)2 ⇌-[r 1 Ch(sr 2).ch:Ch.sr 2(r 2 = Et或bu N)
DOI:10.1039/j39680000746

专利信息

专利号:US-3825569-A
优先权日:1967-12-04
标题 :Synthesis of tricyclic carbocyclic compounds and intermediates therefor
发明人：HAJOS Z; OLIVETO E
权利人:HOFFMANN LA ROCHE
摘要:METHODS FOR THE PREPARATION OF 2,3,3A,4,5,7,8,9,9AB,9BADECAHYDRO - 3AB-PRIMARY LOWER ALKYL-7-OXO-1H-BENZ(E) INDENES AND 4,4AB,4BA,5,6,7,8,8A,9,10-DECAHYDRO-8AB-PRIMARY LOWER ALKYL - 3H-PHENANTHREN-2-ONES BY CYCLIZING COMPOUNDS OF THE FORMULA WHERE R1 IS HYDROGEN OR LOWER ALKYL; Z'' IS CARBONYL OR CH(OR2''); R2'' IS HYDROGEN, LOWER AKYL, LOWER ALKANOYL, BENZOYL, NITROBENZOYL, CARBOXY-LOWER ALKANOYL, CARBOXYBENZOYL, TRIFLUOROACETYL OR CAMPHORSULFONYL; T'' IS -C(X'')=CH-, -C(OR3)=CH- OR -Q''-CH2-; R3 IS LOWER ALKYL; X'' IS BROMINE, CHLORINE OR IODINE; Q'' IS CARBONYL, LOWER ALKYLENE DIOXY-METHYLENE, DI-(LOWER ALKOXY)-METHYLENE OR HYDROXY-METHYLENE, R4 IS LOWER PRIMARY ALKYL AND M IS AN INTEGER HAVING A VALUE OF 1 OR 2. THE COMPOUNDS OF THIS SERIES ARE USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF KNOWN STEROIDS WHICH ARE PHARMACOLOGICALLY ACTIVE AS FERTILITY CONTROL AGENTS. CH3)-) R1-CH2-T''-CH2-CH(-CO-H)-CH<(-CH2-(CH2)M-Z''-C(-R4)(-CH2-

专利号:US-11639326-B2
优先权日:2017-04-06
标 题 :Continuous flow synthesis of ibuprofen
发明人：COLLINS NATHAN; MALERICH JEREMIAH; SZETO JUDY; KOZOCAS JOSEPH A
权利人:STANFORD RES INST INT
摘要:This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-6084108-A
优先权日:1997-10-14
标 题 :Synthesis of 3-carbomethoxy-4,5-dimethylthiophene
发明人：FEVIG THOMAS L; LAU PATRICK H; PHILLIPS WENDELL G
权利人:MONSANTO CO
摘要:Fungicides having thiophene rings may be made from the intermediate compound 3-carbomethoxy-4,5-dimethylthiophene. That compound, and related compounds, may be produced by reacting an alpha mercaptoketone, e.g., 3-mercapto-2-butanone, with an acrylate, e.g., methyl-3-methoxy acrylate, in the presence of an alkoxide base, e.g., NaOMe, to form the substituted tetrahydrothiophene, followed by conversion to the aromatic thiophene with an acid treatment. The substituted tetrahydrothiophene is a novel compound.

专利号:US-4215044-A
优先权日:1979-04-23
标题:Synthesis of α-fluorocarbonyl compounds
发明人：MIDDLETON WILLIAM J
权利人:DU PONT
摘要:Process for preparing an organic compound of the formula R 2 R 2 CFC(O)R 3 , which process comprises contacting and reacting in a reaction mixture which includes an inert solvent, at a temperature of -40° C. to -100° C., ROF and ##STR1## R is polyfluoroperhaloalkyl of 1-6 carbon atoms or FOCF 2 ; R 1 is hydrocarbyl of 1-6 carbon atoms; n each R 2 is selected from H, alkyl of 1-17 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl and such alkyl, cycloalkyl, aryl and heteroaryl substituted by halogen or alkoxy of 1-6 carbon atoms; n R 3 is selected from H, alkyl and haloalkyl of 1-16 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl and haloaryl, OSi(R 1 ) 3 , OH, NH 2 , alkoxy of 1-6 carbon atoms, aryloxy, NHR 1 and NR 1 2 wherein R 1 is alkyl of 1-6 carbon atoms, N-arylamino and nitrogen or sulfur heterocyclic of 4-5 carbon atoms; n R 3 and one R 2 taken together is a diradical which with the Câ•?C group is carbocyclic, heterocyclic or haloheterocyclic, and recovering from the reaction mixture the compound of the formula R 2 R 2 CFC()R 3 .

专利号:US-7067703-B2
优先权日:2001-10-31
标题:Manufacture of retinoids
发明人：RADSPIELER ALEXANDER; RUETTIMANN AUGUST
权利人:DSM IP ASSETS BV
摘要:A process for the manufacture of retinal (I) comprises reacting a 5-(2,6,6-trimethyl-cyclohex-1-enyl)-1,4-pentadiene derivative (IIa) or a 5-(2,6,6-trimethyl-cyclohex-2-enyl)-1,4-pentadiene derivative (IIb) or a 5-(2,6,6-trimethyl-2-cyclohexen-1-ylidene)-1-pentene derivative (IIc) or a 5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-1-en-4-yne derivative (IId) or a 5-(2,6,6-trimethyl-cyclohex-2-enyl)-penta-1-en-4-yne derivative (IIe) with a 1,3-butadiene derivative H2Câ•?C(CH3)CCHâ•?CHOR4 (III) in the presence of a Lewis or Brönsted acid and subjecting the compound obtained in each case [(IVa), (IVb), (IVc), (IVd) or (IVe), respectively] to basic or acidic conditions to eliminate therefrom the moiety R2H and thus produce, according to the immediate precursor, retinal itself or a particular derivative thereof [(I′), (I″), (Va) or (Vb), respectively] and, where in two cases such derivative is produced featuring a triple bond [derivative (Va) or (Vb)], hydrogenating this to produce retinal (I) or the derivative (I′), respectively, and each case where a derivative (I′) or (I″) has been produced, isomerizing this under basic or acidic conditions or in the presence of a metal catalyst to the desired retinal (I). The so-produced retinal is usually in the form of an isomeric mixture, normally as (9 E/Z, 13 E/Z)-retinal, and this can be isomerized according to a further inventive aspect to (all-E)-retinal by the acid-catalyzed formation of an adduct of (all-E)-retinal with hydroquinone in crystalline form. The so obtained (all-E)-retinal-hydroquinone adduct can then if desired be converted to vitamin A alcohol in the predominantly (all-E)-isomeric form by a method known per se. The novel starting materials (IIa), (IIb), (IIc), (IVI) and (IIe) represent a still further inventive aspect. Retinal is a valuable intermediate in the synthesis of further vitamin A compounds (retinoids). The retinoids, particularly vitamin A alcohol (retinol), are known to be valuable substances which promote the well-being of humans, inter alia in respect of vision, the immune system and growth, and for this reason are often used as components of multivitamin preparations and as additives for crtain food- and feedstuffs.

专利号:US-8658400-B2
优先权日:2008-12-17
标题:Biocatalysts for manufacturing duloxetine alcohol
发明人：SCHNEIDER NINA; HOEFFKEN HANS WOLFGANG
权利人:SCHNEIDER NINA; HOEFFKEN HANS WOLFGANG; BASF SE
摘要:The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.