CAS: 87-63-8; 2-Chloro-6-Methylaniline

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2-氨基甲苯-5-磺酸置于盐酸,双氧水,溶剂黄146,Sodium Hydroxide体系中,用 环丁砜,水 作为反应溶剂,化学反应 28.0H,反应生成 2-氯-6-甲基苯胺
参考文献:一种2-氯-6-甲基苯胺的制备方法
标题:一种2-氯-6-甲基苯胺的制备方法
摘要:本发明涉及化学领域,特别是涉及一种高纯度2‑氯‑6‑甲基苯胺的制备方法.本发明提供一种2‑氯‑6‑甲基苯胺的制备方法,包括:将4‑氨基‑3‑甲基苯磺酸和乙酸酐在缚酸剂存在的条件下,制备获得4‑乙酰氨基‑3‑甲基苯磺酸钠;将4‑乙酰氨基‑3‑甲基苯磺酸钠在氯化试剂存在的条件下进行氯化反应,制备获得2‑氯‑4‑乙酰氨基‑3‑甲基苯磺酸;将2‑氯‑4‑乙酰氨基‑3‑甲基苯磺酸进行脱羧反应,制备获得2‑氯‑6‑甲基苯胺.本发明所提供的制备方法中,通过氨基保护,氯化,脱羧反应,并使用了特定的砜类溶剂,减少了在反应中副反应的发生,废液无毒无害,反应操作和后处理方法简单.

专利信息

专利号:WO-9108265-A1
优先权日:1989-12-02
标 题:Azo compounds and their use as dyes, 1-sulpho-6-carboxyl-amino naphthaline, its use as a diazo component and process for the production of these compounds
发明人：SPRINGER HARTMUT; HUSSONG KURT
权利人:HOECHST AG
摘要:The description relates to azo compounds corresponding to formula (1) below, having fibre-reactive properties and making valuable dyes. They can dye hydroxy and/or carbonamide group-containing synthetic and natural materials, especially fibre materials, like wool and especially cellulose fibre materials in bright colours. Formula (1) in which: M is hydrogen or a salt-forming metal like an alkaline metal; K is a residue of general formulae (2A) or (2B) in which: E is the residue of an intermediate component common in disazo dyes which can act as a coupling and as a diazo component, e.g. the residue of a 1-(aminophenyl) or -amino-naphthyl) pyrazolon, aminonaphthol, anilin or 1-amino naphthalin compound; v is the figure zero or 1; K is the residue of a water-soluble coupling component, preferably from the naphthol, aminonaphthol, anilin, pyrazolon, hydroxypyridon and acetoacetyl arylide series, whereby this coupling component contains 1 or 2 fibre-reactive groups of the vinyl sulphonate series; D is a benzol or naphthalin residue, whereby its substituents R?1 and R?2 are common ones in azo dyes, e.g. (besides hydrogen) lower alkyl, lower alkoxy, halogen, sulpho and carboxyl; the group -SO2?-Y is a fibre-reactive group of the vinyl sulphone series; a is the figure zero, 1 or 2; and k is the number 1 or 2. A description is also given of the compound 2-amino naphthaline-1-sulphonic acid-6-carboxylic acid which may be used as a pre-product in the production of dyes, e.g. as diazo component in the synthesis of dyes of general formula (1).

专利号:US-4806687-A
优先权日:1986-04-02
标题 :Catalytic hydrodesulfurization of ortho-aminobenzylsulfides
发明人：BALTHAZOR TERRY M; TREMONT SAMUEL J
权利人:MONSANTO CO
摘要:Ortho-alkylanilines are prepared by catalytic hydrodesulfurization of ortho-aminobenzyl sulfides using a cobalt-molybdenum oxide catalyst. For example, 2-methyl-6-trifluoromethylaniline is prepared by catalytic hydrodesulfurization of 3-trifluoromethyl-2-aminobenzyl sulfides. The substituted anilines prepared by the method of this invention are useful as intermediates in the synthesis of compounds shown to have herbicidal activity.

专利号:EP-0051792-A1
优先权日:1980-11-08
标 题 :Derivatives of hydroxamic-acid esters, process for their preparation and their use as herbicides
发明人：FUEHRER WOLFGANG DR; STETTER JOERG DR; EUE LUDWIG DR; SCHMIDT ROBERT RUDOLF DR
权利人:BAYER AG
摘要:Hydroxamic acid derivatives of the formula in which Y represents oxygen or sulfur, R¹ represents hydrogen, alkyl or alkoxy, R² represents hydrogen, alkyl, alkoxy or halogen, R³ represents hydrogen, alkyl, alkoxy or halogen, R < 4> represents hydrogen or alkyl, R <5> represents alkyl, alkenyl, alkynyl or alkoxyalkyl, R <6> represents hydrogen, alkyl, alkenyl, alkynyl or alkoxyalkyl or R <4> and R <5> together represent one Alkylene chain, or R 5 and R 6 together represent an alkylene chain, provided Y is oxygen and Z is halogen, a process for their preparation and their use as herbicides. N-phenylglycine derivatives of the formula in which Y, R¹, R², R³, R <4>, R <5> and R <6> have the meanings given above, several processes for their preparation and their use as intermediates for the synthesis of the substances of formula (I).

专利号:US-9115124-B1
优先权日:2014-03-11
标题 :Process and intermediates for the preparation of dasatinib
发明人：BARUTO ALESSANDRO; GABOARDI MAURO; CASTALDI MARTA; CASTALDI GRAZIANO
权利人:CERBIOS PHARMA SA
摘要:The present invention relates to a process for the synthesis of dasatinib and to intermediates useful for its preparation.

专利号:WO-2011095125-A1
优先权日:2010-02-02
标 题:Synthesis methods and purification methods of dasatinib
发明人：YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
权利人:NAN JING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD; YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
摘要:Synthesis methods of dasatinib are provided, which comprise the following steps: reacting a compound of formula I with a compound of formula II to obtain a compound of formula III, and then connecting the compound of formula III with 2-chloro-6-methylaniline and 1-(2-hydroxyethyl)piperazine in any order to give dasatinib. Furthermore, purification methods of dasatinib are also provided.

专利号:US-9108954-B2
优先权日:2010-02-02
标 题:Synthesis process of dasatinib and intermediate thereof
发明人：YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
权利人:YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG; NAN JING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD
摘要:Synthesis process of dasatinib is disclosed, which includes the step of reacting the compound of formula I with that of formula II to obtain the compound of formula III. Also disclosed is the compound of formula III which is used as an intermediate for synthesizing dasatinib. The substituents of R1, R2, R3 or R4 in formulae I, II or III are defined as in the description.