CAS: 34381-71-0; (S)-(-)-1-Methyl-2-Pyrrolidinemethanol

相似化合物

148625-77-8 170491-63-1 53912-80-4

上下游产品

CAS号147-85-3 脯氨酸 | CAS号50-00-0 甲醛 | CAS号23356-96-9 L-脯氨醇 | CAS号59936-29-7 (S)-1-叔-丁基-2-甲基... | CAS号475-11-6 N-甲基-L-脯氨酸 | CAS号13200-83-4 N-甲酰基-L-脯氨酸 | CAS号1148-11-4 N-CBZ-L-脯氨酸 | CAS号5211-23-4 N-Z-L-脯氨酸甲酯 | CAS号27957-91-1 (S)-Methyl1-met... | CAS号191161-15-6 3-hex-1-ynyl-5-... | CAS号102156-75-2 (1-methylpyrrol... | CAS号161417-05-6 2-methyl-5-[[(2... | CAS号28808-26-6 (3R)-1-甲基哌啶-3-醇 | CAS号852324-29-9 (S)-1-Methyl-py...

N-甲基-L-脯氨酸甲酯置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 N-甲基-L-脯氨醇
参考文献:新型t型钙通道拮抗剂的设计,合成和生物学评估.
标题:新型t型钙通道拮抗剂的设计,合成和生物学评估.
摘要:本文描述了几种抑制钙流入细胞的新型t型钙通道拮抗剂的合成,后者又调节了细胞周期途径中负责细胞增殖的未知方面.合成了化合物文库,并将描述简要的结构活性关系.从这些研究中,我们已经确定了一种化合物(1),在多种癌细胞系中都具有低微摩尔范围的抗增殖活性.
DOI:10.1016/j.Bmcl.2004.05.011

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-12172982-B2
优先权日:2020-08-12
标 题:Synthesis of quinazoline compounds
发明人：LIM NGIAP-KIE; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BIGLER RAPHAEL; CLAGG KYLE BRADLEY PASCUAL; DIPASQUALE ANTONIO GIOVANNI; GOSSELIN FRANCIS; ORCEL UGO JONATHAN; MEIER ROLAND CHRISTOPH
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.

专利号:US-2024400558-A1
优先权日:2021-09-09
标题 :Processes and intermediates for synthesis of adagrasib
发明人：SCATTOLIN THOMAS; CHEN CHENG; GHARBAOUI TAWFIK; GAN YONGHONG; ACHMATOWICZ MICHAL; SNEAD DAVID
权利人:MIRATI THERAPEUTICS INC
摘要:The present invention relates to improved synthetic routes of synthesizing adagrasib. The invention also provides intermediates used in the provided synthetic routes.

专利号:US-12071422-B2
优先权日:2022-02-07
标 题 :Process for synthesis of quinazoline compounds
发明人：LEBL RENE; LIM NGIAP KIE; MEIER ROLAND CHRISTOPH; ORCEL UGO JONATHAN; SEDELMEIER JOERG; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BASS THOMAS MICHAEL; BIGLER RAPHAEL; BURKHARD JOHANNES ADRIAN; CLAGG KYLE BRADLEY PASCUAL; GOSSELIN FRANCIS; HAN CHONG; KALDRE DAINIS; KELLY SEAN M; HEROLD SEBASTIAN; LEITNER CHRISTIAN
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

专利号:WO-2023205074-A1
优先权日:2022-04-18
标 题:Processes and intermediates for synthesis of adagrasib
发明人：SCATTOLIN THOMAS; GAN YONGHONG; CHEN CHENG; CHEN CHENGSHENG
权利人:MIRATI THERAPEUTICS INC
摘要:The present invention relates to new synthetic routes of synthesizing adagrasib. The invention also provides intermediates used in the provided synthetic routes.