CAS: 374633-32-6; 2-Chloro-3-Fluoro-6-Methylpyridine

该化合物是一种环环状有机化合物,其特点是用氯,氟和甲基组来替代环,这些替代物的存在影响其化学特性,使它成为极分子,具有各种相互作用的潜力.一般而言,该化合物具有温和的沸点和熔点,反映其分子结构.它溶于乙醇和丙酮等有机溶剂,但由于其缺水性甲基组和卤素的存在,在水中溶解性可能有限.氯和氟原子有助于其再活动,使其能够参与核分裂性替代反应.该化合物对制药和农用化学研究具有兴趣,因为其独特的结构可能带来具体的生物活动.应当参考安全数据,因为卤化化合物可能对健康造成风险,包括毒性和环境关切.在实验室中与该物质打交道时,适当的处理和处置程序是必不可少的.

英文名称2-Chloro-3-Fluoro-6-Methylpyridine
中文名称2-氯-3-氟-6-甲基吡啶
IUPAC名称2-chloro-3-fluoro-6-methylpyridine
其它别名2-Chloro-3-fluoro-6-methylpyridine
CAS编号374633-32-6
MFCD编号:MFCD03095216
分子式:C6H5ClFN
分子量:145.56
产品CID: 1384634
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: BGDYLOGCMJAUHR-UHFFFAOYSA-N
InChI=1S/C6H5ClFN/c1-4-2-3-5(8)6(7)9-4/h2-3H,1H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数0.0

相似化合物

884494-78-4 1159512-39-6 17282-04-1

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

合成工艺路线路线简述

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-11739065-B2
优先权日:2016-06-13
标题 :FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; GEGE CHRISTIAN; KROPF JEFFREY E; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-11225473-B2
优先权日:2019-01-15
标题:FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; FRICK MORIN MAE; HORSTMAN ELIZABETH M; KAPLAN JOSHUA A; KROPF JEFFREY E; WATKINS WILLIAM J
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:CN-119462496-A
优先权日:2023-08-08
标题:Synthesis method of 2-chloro-3-fluoro-6-methylpyridine-4-amine