CAS: 3943-89-3; Ethyl 3,4-Dihydroxybenzoate

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CAS号99-50-3 原儿茶酸 | CAS号64-17-5 乙醇 | CAS号20986-39-4 3,4-二氢-2H-苯并[b]... | CAS号120-47-8 尼泊金乙酯 | CAS号7647-01-0 盐酸 | CAS号476168-17-9 2-氨基-4,5-双(2-甲氧... | CAS号3943-77-9 3,4-二甲氧基苯甲酸乙酯 | CAS号39635-11-5 3,4-二羟基苯甲酰肼 | CAS号1486-54-0 3,4-二(苄氧基)苯甲酰氯 | CAS号148527-38-2 3-羟基-4-甲氧基苯甲酸乙酯 | CAS号39270-39-8 苯并二氧六环-6-甲醇 | CAS号180678-33-5 3,4-dihexadecox... | CAS号179688-14-3 3,4-双{[2-(甲基氧基)... | CAS号99-50-3 原儿茶酸 | CAS号20825-87-0 ETHYL 2,3-DIHYD...

香草酸乙酯置于aluminium(III) Iodide,N,N-二甲基甲酰胺二甲基缩醛体系中,用 乙腈 用作溶剂,化学反应 18.0H,以94%的收率获得3,4-二羟基苯甲酸乙酯
参考文献:三碘化铝和n,N-二甲基甲酰胺二甲基乙缩醛对酸不稳定的芳烷基醚的手性辅助选择性裂解.
标题:三碘化铝和n,N-二甲基甲酰胺二甲基乙缩醛对酸不稳定的芳烷基醚的手性辅助选择性裂解.
摘要:N,N-二甲基甲酰胺二甲基乙缩醛(dmf-Dma)利用三碘化铝通过相邻基团的参与选择性裂解醚.包括羧酸盐,烯丙基,叔丁基二甲基甲硅烷基(tbs)和叔丁氧羰基(boc)在内的各种酸不稳定官能团均完好无损.该方法为裂解邻苯二酚单烷基醚和从乙缩醛型保护基(如甲氧基甲基(mom),甲氧基乙氧基甲基(mem)和四氢吡喃基(thp))上化学选择性解吸酚提供了一种有效的方法.
Doi:10.1021/acs.Joc.0C00290

专利信息

专利号:US-8921312-B2
优先权日:2006-06-05
标题 :Combination of insulin and ascorbate to enhance wound healing
发明人：MUSSELMANN KURT; HASSELL JOHN R; KANE BRAD; ALEXANDROU BRIDGETTE
权利人:MUSSELMANN KURT; HASSELL JOHN R; KANE BRAD; ALEXANDROU BRIDGETTE; UNIV SOUTH FLORIDA
摘要:Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.

专利号:WO-2007145934-A1
优先权日:2006-06-05
标题 :Combination of insulin and ascorbate to enhance wound healing
发明人：MUSSELMANN KURT; HASSELL JOHN R; KANE BRAD; ALEXANDROU BRIDGETTE
权利人:UNIV SOUTH FLORIDA; MUSSELMANN KURT; HASSELL JOHN R; KANE BRAD; ALEXANDROU BRIDGETTE
摘要:Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.

专利号:US-9359370-B2
优先权日:2008-07-08
标题 :Icotinib hydrochloride, synthesis, crystalline forms, pharmaceutical compositions, and uses thereof
发明人：WANG YINXIANG; XIE GUOJIAN; DING LIEMING; TAN FENLAI; HU YUNYAN; HE WEI; HAN BIN; LONG WEI; LIU YONG; Ai haima; DAVIS CHARLES; ZHANG DON
权利人:BETA PHARMA INC
摘要:The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.

专利号:US-8133999-B2
优先权日:2003-07-30
标题 :Process for preparation of 6, 7-bis(2-methoxyethoxy) quinazolin-4-one
发明人：NISHINO SHIGEYOSHI; HIROTSU KENJI; SHIMA HIDETAKA; ODA HIROYUKI; SUZUKI SHINOBU
权利人:NISHINO SHIGEYOSHI; HIROTSU KENJI; SHIMA HIDETAKA; ODA HIROYUKI; SUZUKI SHINOBU; UBE INDUSTRIES
摘要:6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate of formula (4) with an orthoformic acid in the presence of an ammonium acetate:

专利号:US-11162129-B2
优先权日:2016-11-09
标 题 :Photoprotective mixtures as imaging reagents in sequencing-by-synthesis
发明人：ANDRUZZI LUISA; Perbost Michel Georges; HEVRONI DONA; GUHA MINAKSHI; RICKER AUSTIN; PELLETIER TIMOTHY
权利人:ISOPLEXIS CORP
摘要:The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods. In particular, the present invention contemplates the use of photoprotective mixture of compounds as imaging reagents to improve stability and storage of fluorescent compounds, including but not limited to, nucleotides with fluorescent labels.

专利号:US-2023293530-A1
优先权日:2020-06-24
标 题:Agents for sensitizing solid tumors to treatment
发明人：EREZ AYELET; KESHET ROM; ADLER LITAL; RUPPIN EYTAN; SANG LEE JOO
权利人:YEDA RES & DEV; THE US SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVIC
摘要:An agent which increases pyrimidine to purine ration in a cell without decreasing pyrimidine synthesis for use in a method of treating a solid tumor in a subject in need thereof, optionally in combination with an immune-modulating drug.