CAS: 402-65-3; 2-Fluoroisonicotinic Acid

相似化合物

3939-14-8 131747-69-8 131747-60-9

上下游产品

CAS号461-87-0 2-氟-4-甲基吡啶 | CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号455-69-6 2-氟吡啶-4-甲酸甲酯 | CAS号369-24-4 2-氟异烟肼 | CAS号131747-69-8 2-氟吡啶-4-甲醛 | CAS号131747-60-9 2-氟-4-吡啶甲醇 | CAS号123412-43-1 N-(2-氟吡啶-4-羰基)-l-脯氨酸 | CAS号369-01-7 2-氟-4-吡啶羧酰胺 | CAS号65352-95-6 2-氟吡啶-4-乙酰氯 | CAS号868734-50-3 2-(4-Fluoroanil... | CAS号885588-03-4 3-(2-氟-4-碘苯基氨基)...

2-氨基-4-甲基吡啶置于potassium Permanganate,Tetrafluoroboric Acid,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应生成 2-氟异烟酸
参考文献:新型1,4-二氢吡啶类钙拮抗剂.i.4-(取代的吡啶基)-1,4-二氢吡啶衍生物的合成和降血压活性.
标题:新型1,4-二氢吡啶类钙拮抗剂.i.4-(取代的吡啶基)-1,4-二氢吡啶衍生物的合成和降血压活性.
摘要:合成了一系列4-(取代的吡啶基)-1,4-二氢吡啶衍生物,并研究了它们的降压作用.几种化合物,2-(n-苄基-N-甲基氨基)乙基甲基1,4-二氢-2,6-二甲基-4-(3-硝基-2-吡啶基)-3,5-吡啶二甲酸(2B),4-(4-硝基-2-吡啶基)类似物(2G),4-(3-三氟甲基-2-吡啶基)类似物(2C),4-(2-三氟甲基-3-吡啶基)类似物(3E),4-发现(4-氰基-2-吡啶基)类似物(2E),4-(2-氰基-3-吡啶基)类似物(3D)和4-(6-溴-2-吡啶基)类似物(2I)具有与尼卡地平类似的降压活动;特别是2C和3E的持续时间约为尼卡地平的两倍,而2E具有在所有合成衍生物中最有效的降压活性.
DOI:10.1248/cpb.38.2446

专利信息

专利号:US-2023295613-A1
优先权日:2020-02-14
标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming
发明人：JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:US-11814621-B2
优先权日:2018-06-01
标题 :Expanding the chemical substrates for genetic code reprogramming
发明人：JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; MOORE JEFFREY S; SCHWIETER KENNETH E; SCHWARZ KEVIN JEROME
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:WO-2011095593-A1
优先权日:2010-02-08
标 题 :Iodo precursor for a pet imaging agent of amyloid plaques
发明人：SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
权利人:BAYER SCHERING PHARMA AG; SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
摘要:The invention relates to a precursor for a [ 18 F]-labeled PET tracer for imaging of Alzheimer's Disease, its synthesis and the process for preparing the respective [ 18 F]-labeled PET tracer.

专利号:US-2008058528-A1
优先权日:2006-07-20
标题 :Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile

专利号:WO-2016097351-A1
优先权日:2014-12-19
标题:18f labelled thiazolylhydrazone derivatives
发明人：JACKSON ALEXANDER; MORISSON-IVESON VERONIQUE; WYNN DUNCAN GEORGE; JOSE JINTO; RANGASWAMY CHITRALEKHA
权利人:GE HEALTHCARE LTD
摘要:The present invention relates to compounds of Formula (I) wherein R 1 and R 2 are independently selected from 19 F and 18 F having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive compounds. The radioactive compounds of the invention can find use for in vivo imaging applications.

专利号:EP-2057145-B1
优先权日:2006-07-20
标 题:Synthesis of (2s,5r)-5-ethynyl-1-{n-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile