CAS: 73-78-9; Lidocaine Hydrochloride

上下游产品

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide diethylamine chloroacetyl chloride 2,6-dimethylanilineN-(2,6-dimethylphenyl)-2-ethylaminoacetamide lid°Cainium acetylsalicylate 1-ethyl-2-methyl-3-(2,6-dimethylphenyl)imidazolidin-4-one

利多卡因置于盐酸体系中,用 乙醚 作为反应溶剂,以100%的收率获得产物盐酸利多卡因
参考文献:利多卡因盐酸盐一水合物的分子结构和振动,(1)h和(13)c NMR光谱.
标题:利多卡因盐酸盐一水合物的分子结构和振动,(1)h和(13)c NMR光谱.
摘要:通过b3Lyp / 6-311G(*∗)计算研究了局部麻醉药利多卡因盐酸盐一水合物盐的结构,振动和NMR光谱.利多卡因.hcl.h2O盐预计在室温下具有主要形式的薄纱状结构,Nccn和cncc扭转角分别为110°和-123°,而基础利多卡因分别为10°和-64°.两个nh键之间的排斥相互作用破坏了利多卡因.hcl.h2O盐的gauche结构的稳定性.所观测到的振动光谱的分析与室温下仅一种乳脂状构象中利多卡因盐的存在是一致的.利多卡因.hcl.h2O的(1)h和(13)c NMR光谱通过实验和dft计算得出的利多卡因盐的化学位移进行了解释.
DOI:10.1016/j.Saa.2015.07.060

专利信息

专利号:US-6264962-B1
优先权日:1997-12-19
标 题:Use of cinnamic acid or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids. n The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:US-6660283-B2
优先权日:1997-12-19
标 题 :Use of cinnamic acid, or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids.The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:WO-9925385-A1
优先权日:1997-11-17
标 题:A method of increasing nucleic acid synthesis with ultrasound
发明人：UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
权利人:IMARX PHARMACEUTICAL CORP
摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

专利号:US-8178501-B2
优先权日:2004-12-17
标 题:Antibiotic combinations for providing total solution to the treatment of infections
发明人：CHAUDHARY MANU
权利人:CHAUDHARY MANU; VENUS REMEDIES LTD
摘要:The invention relates to a new pharmaceutical composition, a method of treatment of infection and also a process to prepare the composition. The infectious complications are important causes of morbidity and mortality. Hospital acquired pneumonia (HAP) remains the most severe nosocomial infection in intensive care units. Beta-lactams alone are always considered inadequate when P. aeruginosa and/or methicillin-resistant S. aureus are implicated as pathogens or copathognes. The present invention provides the desired empirical therapy for control of all bacterial infections. The invention provides antibiotic combination products for delivering at least two different antibiotics, through parenteral dosage form comprising protein-synthesis-inhibiting antibiotic which is amikacin or its sulphate salt and non-protein-synthesis-inhibiting antibiotic which is cefepime or its hydrochloride salt. The invention provides a total solution, against multiresistant P. aeruginosa , or Acinetobacter spp. and/or methicillin-resistant S. aureus , and are useful for intramuscular or intravenous administration as antibiotics for hospitalized patients with acute or serious infections. The pharmaceutical compositions described here normally have the least nephrotoxicity and have better efficacy and safety of cefepime plus amikacin combination.

专利号:US-9687428-B2
优先权日:2001-05-01
标题 :Hydrogel compositions for tooth whitening
发明人：SINGH PARMINDER; CLEARY GARY W; MUDUMBA SRI; FELDSTEIN MIKHAIL M; BAYRAMOV DANIR F
权利人:A V TOPCHIEV INST OF PETROCHEMICAL SYNTHESIS RUSSIAN ACAD OF SCIENCES; CORIUM INT INC; A V TOPCHIEV INST OF PETROCHEMICAL SYNTHESIS RUSSIAN ACAD OF SCIENCES
摘要:A composition is provided, wherein the composition comprises a water-swellable, water insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to the teeth in need of whitening, and then removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

专利号:US-2003138490-A1
优先权日:2001-09-08
标 题 :Synthesis and uses of polymer gel nanoparticle networks
发明人：HU ZHIBING; LU XIHUA; GAO JUN; PONDER BILL C; JOHN JOHN ST; MORO DANIEL G
摘要:Disclosed is a new class of nanostructured polymeric materials comprising polymer gel nanoparticles that are covalently bonded through functional groups on the surfaces of neighboring particles. These nanoparticles may be prepared as suspensions in an aqueous or, non-aqueous environment. These gels have two unique and different structural networks; the primary network comprises crosslinked polymer chains in each individual particle, while the secondary network is a system of crosslinked nanoparticles. Particular polymer gel nanoparticle network compositions disclosed herein may function as carriers for controlled delivery of pharmaceuticals or other chemical agents, gel sensors and other commercial applications.