CAS: 81945-73-5; 1H-Pyrazol-1-Ol

英文名称1H-Pyrazol-1-Ol
中文名称1-羟基吡唑
IUPAC名称1H-pyrazol-1-ol
其它别名1-hydroxy-1H-pyrazole; 1H-Pyrazol-1-ol; 1H-Pyrazole, 1-hydroxy-
CAS编号81945-73-5
MFCD编号:MFCD11850516
EINECS号:279-854-3
分子式:C3H4N2O
分子量:84.08
产品CID: 1811458
产品分类有机原料→分子砌块→芳杂环类化合物→吡唑类化合物

相似结构搜索
产品信息参考
InChIKey: QVCIPIYWPSPRFA-UHFFFAOYSA-N
InChI=1S/C3H4N2O/c6-5-3-1-2-4-5/h1-3,6H…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数0.0

相似化合物

437701-80-9 17536-00-4 30433-57-9

MSDS等安全信息

GHS符号GHS07
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

145162-47-6 = 81945-73-5
反应条件:1.1 Reagents: Hydrochloric Acid,Trimethylsilyl Iodide Solvents: Chloroform
标题:Preparation Of 1-Hydroxypyrazoles And 1-Hydroxy-1,2,3-Triazoles By Dealkylation Of Pyrazole And Triazole N-Oxides
作者:Begtrup,Mikael; Vedsoe,Per
参考文献:Acta Chemica Scandinavica 日期:1996 卷标:50(6) 页码:549-555]

288-13-1 = 81945-73-5
反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Ethyl Acetate
标题:Preparation Of N-Hydroxyazoles By Oxidation Of Azoles
作者:Begtrup,Mikael; Vedsoe,Per
参考文献:Journal Of The Chemical Society 日期:1995 卷标:(3) 页码:243-7]

288-13-1 = 81945-73-5
反应条件:1.1 Reagents: Benzoyl Peroxide,Potassium Hydroxide Catalysts: Benzyltriethylammonium Chloride Solvents: Toluene
标题:Identification Of Quinoxalin-2(1H)-One Derivatives As A Novel Class Of Multifunctional Aldose Reductase Inhibitors
作者:Hao,Xin; Qin,Xiangyu; Zhang,Xin; Ma,Bing; Qi,Gang; Et Al
参考文献:Future Medicinal Chemistry 日期:2019 卷标:11(23) 页码:2989-3004]

288-13-1 = 81945-73-5 [标题:Reaction Conditions
标题:Preparation Of N-Hydroxypyrazoles
参考文献:Federal Republic Of Germany]

288-13-1 = 81945-73-5
反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran1.2 Reagents: Benzoyl Peroxide Solvents: Tetrahydrofuran
标题:A Facile Synthesis Of 1-Hydroxypyrazole By Oxidation Of Pyrazole
作者:Reuther,Wolfgang; Baus,Ulf
参考文献:Liebigs Annalen 日期:1995 卷标:(8) 页码:1563-6]

288-13-1 = 81945-73-5 [标题:Reaction Conditions
标题:Partial Agonists And Subunit Selectivity At Nmda Receptors
作者:Risgaard,Rune; Hansen,Kasper B.; Clausen,Rasmus P.
参考文献:Chemistry - A European Journal 日期:2010 卷标:16(47) 页码:13910-13918]

3355-28-0 = 81945-73-5 [标题:Reaction Conditions
标题:Electrochemical Preparation Of Alkoxyacetic Acids
参考文献:Federal Republic Of Germany

1-(苄氧基)吡唑置于palladium On Activated Charcoal 氢气体系中,用甲醇作为反应溶剂,化学反应 0.5H,以93%的收率获得产物n-(3-氨基丙基)丙烷-1,3-二胺-2-(氯甲基)噁丙环(1:1)
参考文献:Synthesis Of 5-Substituted 1-Hydroxypyrazoles Through Directed Lithiation Of 1-(Benzyloxy)Pyrazole
标题:Synthesis Of 5-Substituted 1-Hydroxypyrazoles Through Directed Lithiation Of 1-(Benzyloxy)Pyrazole
摘要:1-Hydroxypyrazoles Have Been Converted To 1-(Benzyloxy),[(9-Phenylfluorenyl)Oxy],[(N,N-Diethylcarbamoyl)Oxy],And (-Silyloxy)Pyrazoles. 1-(Benzyloxy)Pyrazole Was Lithiated Selectively In The 5-Position. Subsequent Reaction With Electrophiles Gives Rise To 1-(Benzyloxy)Pyrazole With Carbon,Halogen,Silicon,Sulfur,Or Tin Substituents At The 5-Position. 1-(Benzyloxy)Pyrazoles Could Be Debenzylated By Hydrogen Bromide Or Hydrogenolysis Producing 5-Substituted 1-Hydroxypyrazoles In High Overall Yield.
DOI:10.1021/jo00121A017