CAS: 16461-94-2; 4-Bromo-1H-Pyrazol-3-Amine

相似化合物

89717-64-6 1780-72-9 1820-80-0

上下游产品

3-氨基吡唑 3-Aminopyrazole 1820-80-0

3-氨基吡唑 反应生成3-氨基-4-溴吡唑
参考文献:Synthesis Of Substituted Pyrazolopyrimidines
标题:Synthesis Of Substituted Pyrazolopyrimidines
摘要:制备取代的吡唑嘧啶的方法,尤其是n-甲基-N-(3-[3-(2-噻吩甲酰基)吡唑-[1,5-α]嘧啶-7-基]苯基)乙酰胺.此类化合物在广泛的适应症中具有用途,包括治疗失眠.在本发明的实践中,公开了不需要使用和/或分离吡唑中间体的改进技术,以及制备反应中间体本身的改进技术.这些技术具有显著的优点,包括增强效率,特别是在大规模制造的情况下.

专利信息

专利号:US-7034154-B2
优先权日:1999-08-10
标 题:Synthesis of substituted pyrazolopyrimidines
发明人：GROSS RAYMOND S; WILCOXEN KEITH M; OGLESBY RICHARD CHRISTOPHER
权利人:NEUROCRINE BIOSCIENCES INC
摘要:Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide. Such compounds have utility over a wide range of indications, including treatment of insomnia. In the practice of the present invention, improved techniques which do not require use and/or isolation of the pyrazole intermediate are disclosed, as well as improved techniques for making the reaction intermediates themselves. Such techniques offer significant advantages, including enhanced efficiency, particularly in the context of large scale manufacture.

专利号:US-6472528-B1
优先权日:1999-08-10
标题 :Synthesis of substituted pyrazolopyrimidines

专利号:US-2003004346-A1
优先权日:1999-08-10
标题:Synthesis of substituted pyrazolopyrimidines

专利号:CN-114874221-A
优先权日:2022-05-12
标 题:A kind of RIP2 kinase inhibitor intermediate and its synthesis method