1,3-二氟苯置于氯化亚砜,氨体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成2,6-二氟苯腈 参考文献:The Synthesis And Activity Of Some 2,6-Difluorophenyl-Substituted Compounds 标题:The Synthesis And Activity Of Some 2,6-Difluorophenyl-Substituted Compounds 摘要: Doi:10.1021/jm00310A026
专利号:WO-0027627-A1 优先权日:1998-11-12 标题 :Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles 发明人:WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO 权利人:LILLY CO ELI; WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO 摘要:In its first aspect, the invention is directed to a solid support mediated method for the synthesis of diverse polycyclic heterocycles according to general formula (V). A second aspect of the invention is directed to a solid support bound intermediate compound that optionally can be derivatized before a cyclization and displacement procedure provides a product. The intermediate is preferably stable to a wide range of chemical conditions thus allowing, if desired, for the chemical derivatization of the intermediate. A third aspect of the invention is directed to a library of polycyclic heterocycle compounds where said library contains a plurality of diverse library compounds of general formula (V). A fourth aspect of the invention is directed to a method for the synthesis of a library of diverse polycyclic heterocycles by the general method described. A fifth aspect of the invention is directed to an assay kit for the identification of lead compounds of the library described therein.
专利号:US-4822903-A 优先权日:1981-05-15 标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof 发明人:JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT 权利人:RHONE POULENC SPEC CHIM 摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.
专利号:FR-3094718-A1 优先权日:2019-04-05 标 题:Process for the synthesis of semi-aromatic polyethers
专利号:CN-1359890-A 优先权日:2001-12-11 标题 :Synthesis of 3,5-Ditrifluoromethylphenyl-hydroquinone
专利号:CN-117659414-A 优先权日:2023-12-04 标题:Synthesis of rigid-flexible amphiphilic polyarylether block copolymer and preparation of fluorescent composite microspheres thereof
专利号:CN-109535413-A 优先权日:2018-12-03 标题 :Synthesis of Polyarylether Nitriles Containing Amino Functional Groups in Side Chains
[参考文献]: C Eriksson, Et Al. Tissue-Binding And Toxicity Of Compounds Structurally Related To The Herbicide Dichlobenil In The Mouse Olfactory Mucosa. Food Chem Toxicol. 1992 Oct;30(10):871-7. [参考文献]: Chenfeng He, Et Al. Tuning Surface Hydrophilicity/hydrophobicity Of Hydrocarbon Proton Exchange Membranes (Pems). J Colloid Interface Sci. 2016 Mar 15:466:168-77.
合成参考文献
参考文献:10.1107/s160053681101083x 摘要:Xu X, Feng L, Li X. Cyanidotetra-kis-(trimethyl-phosphine)cobalt(I). Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):m503.