CAS: 3278-31-7; 1,1'-(1,4-Phenylene)Bis(1H-Pyrrole-2,5-Dione)

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CAS号108-31-6 顺酐 | CAS号106-50-3 对苯二胺

马来酸酐,对苯二胺置于sodium Acetate,乙酸酐体系中,用 丙酮 作为反应溶剂,化学反应 2.5H,反应生成 N,N'-(1,4-亚苯基)双马来酰亚胺
参考文献:某些新型双(二氢吡咯并[3,4-C]吡唑类化合物)的合成,Uv-Vis光谱和hammett相关性
标题:某些新型双(二氢吡咯并[3,4-C]吡唑类化合物)的合成,Uv-Vis光谱和hammett相关性
摘要:摘要通过使由相应的酰肼基氯化物就地反应生成的c,N-苯基取代的腈亚胺与双马来酰亚胺反应,获得了二十九种新型的双(二氢吡咯并[3,4-C]吡唑)衍生物.通过物理和光谱方法[mp,R F,红外(ir),1 H核磁共振(NMR),13 C NMR,相关光谱(cosy),异核相关(hetcor),核overhauser效应(noe)阐明了结构)和高分辨率质谱(hrms)].此外,哈米特常数之间获得哈米特相关图表σ P和λ 最大的双(pyrrolopyrazoles)值携带p取代的带苯基环的吸电子和供电子基团,并根据取代基效应进行讨论. 图形概要 .
DOI:10.1007/s00706-010-0351-Z

专利信息

专利号:US-5262524-A
优先权日:1990-03-09
标题 :Method for the synthesis of trifunctional maleimide-antibody complex
发明人：ANDERSON LESLIE D; AHLEM CLARENCE N; HUANG ANN E
权利人:HYBRITECH INC
摘要:The present invention is directed to a method for extending the length of one of the three linker arms of the compound of Formula I in the production of novel trifunctional antibody-like compounds. Formula I is defined as follows: wherein X is wherein k=1 or 0; wherein Z is wherein s=1 or 0; wherein n=1 or 0; wherein q=1 or 0; wherein Y is wherein Y' is wherein p or m may be the same or different and are integers ranging from 0 to 20 with the provisos that when n=0, the sum of m and p is an integer ranging from 1 to 20, whereas when n=1, p and m are each an integer that is at least 1 and the sum of p and m is an integer ranging from 2 to 20; wherein R1 is straight or branched chain lower alkyl having from 1 to 6 carbon atoms or lower alkoxy having from 1-6 carbon atoms; and wherein R2 is hydrogen, phenyl, -COOH, or straight or branched chain lower alkyl having from 1-6 carbon atoms, with the proviso that the lower alkyl moiety may be mono substituted by -NH2, -OH, or -COOH. The compound of the present invention is useful as a trivalent coupling agent for linking Fab'-like fragments to form both bifunctional and trifunctional antibody-like compounds.

专利号:EP-1534734-B1
优先权日:2002-08-30
标题:Method for the synthesis and selective biocatalytic modification of peptides, peptide mimetics and proteins
发明人：BORDUSA FRANK; WEHOFSKY NICOLE; RUDOLPH RAINER
权利人:ROCHE DIAGNOSTICS GMBH; HOFFMANN LA ROCHE
摘要:Method for synthesis and/or selective N-terminal modification of peptides, peptide mimetics and/or proteins (A). Method for synthesis and/or selective N-terminal modification of peptides, peptide mimetics and/or proteins (A) comprises: (1) preparing an amino component (I) containing at least one amino acid (aa); (2) preparing a carboxy component (II) that has a leaving group on carboxy and contains at least one aa, or a marker or reporter group; and (3) reacting (I) and (II) in a medium that contains at least one ionic fluid, in presence of protease, peptidase and/or hydrolase, so that (I) and (II) become linked through a peptide bond, with cleavage of the leaving group.

专利号:WO-2009006434-A1
优先权日:2007-06-29
标题:One-pot synthesis of nanoparticles and liquid polymer for rubber applications

专利号:US-5091542-A
优先权日:1990-03-09
标 题:Tris-maleimido compounds as intermediates in trifunctional antibody synthesis
发明人：AHLEM CLARENCE; HUANG ANN E
权利人:HYBRITECH INC
摘要:The present invention is directed to a compound for use as an intermediate in the production of novel trifunctional antibody-like compounds. More particularly, the present invention is directed to a compound of the formula: ##STR1## wherein X is ##STR2## wherein k=1 or 0; n wherein Z is ##STR3## wherein s=1 or 0; n wherein n=1 or 0; n wherein q=1 or 0; n wherein Y is ##STR4## wherein Y', is ##STR5## wherein p or m may be the same or different and are integers ranging from 0 to 20 with the proviso that when n=0, the sum of m and p is an integer ranging from 1 to 20, whereas when n=1, p and m are each an integer that is at least 1 and the sum of p and m is an integer ranging from 2 to 20; n wherein R 1 is straight or branched chain lower alkyl having from 1 to 6 carbon atoms or lower alkoxy having from 1-6 carbon atoms; and n wherein R 2 is hydrogen, phenyl, --COOH, or straight or branched chain lower alkyl having from 1-6 carbon atoms, with the proviso that the lower alkyl moiety may be mono substituted by --NH 2 , --OH, or --COOH. n The compound of the present invention is useful as a trivalent coupling agent for linking Fab'-like fragments to form both bifunctional and trifunctional antibody-like compounds.

专利号:US-2016208036-A1
优先权日:2013-09-05
标 题:Synthesis of cross-linked plant-oil based polymers using bismaleimides as crosslinkers

专利号:EP-2167557-A1
优先权日:2007-06-29
标 题:One-pot synthesis of nanoparticles and liquid polymer for rubber applications