CAS: 51776-71-7; 1-Bromo-4-(Difluoromethyl)Benzene

上下游产品

4-bromo-benzaldehyde 2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester 2-(4-bromophenyl)-2,2-difluoroacetic acid 1,4-bromoiodobenzene ((4-bromophenyl)methylene)dibenzene 2-(4-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane N-(5-(4-(difluoromethyl)phenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine 5-{5-[4-(difluoromethyl)phenyl]-1-methyl-1H-pyrazol-4-yl}-N,7-dimethylimidazo[5,1-f][1,2,4]triazin-4-amine

对溴苯甲醛置于potassium Fluoride,甲酸,四甲基氟化铵,N,N-硫酰二咪唑体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,以87%的收率获得产物1-溴-4-(二氟甲基)苯
参考文献:硫酰氟和四甲基氟化铵在室温下对苯甲醛和α-酮酸酯进行脱氧氟化
标题:硫酰氟和四甲基氟化铵在室温下对苯甲醛和α-酮酸酯进行脱氧氟化
摘要:描述了使用硫酰氟和me 4 Nf在室温下对苯甲醛和α-酮酸酯进行脱氧氟化的方法.证明了大范围的芳基和杂芳基底物,并且该方法与许多底物的其他常见脱氧氟化方法相比具有优势.
DOI:10.1021/acs.Orglett.9B00054

专利信息

专利号:WO-2023057548-A1
优先权日:2021-10-07
标题:Ccr6 receptor modulators
发明人：AISSAOUI HAMED; ALLEMANN OLIVER; CAROFF EVA; MEYER EMMANUEL; RICHARD-BILDSTEIN SYLVIA
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.

专利号:CN-117185897-A
优先权日:2023-08-31
标 题 :A kind of synthesis method of difluoromethyl halobenzene

专利号:US-9957277-B2
优先权日:2015-11-25
标题 :eIF4A-inhibiting compounds and methods related thereto
发明人：ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; TRAN CHINH VIET; PACKARD Garrick Kenneth; XIANG ALAN X; NILEWSKI CHRISTIAN; MICHELS THEO
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b and R 5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.